Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]

[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

10 Item(s)

per page
Axon ID Name Description From price
3410 UTL-5g TNFα modulator €120.00
1507 TMI 005 TACE/MMP inhibitor €150.00
2300 TIC10 active isomer Small molecule that transcriptionally induces TRAIL €120.00
3324 Thalidomide TNFα inhibitor. Immunomodulator. €50.00
2143 SPD 304 Cell permeable inhibitor of TNFα €145.00
3166 Pomalidomide TNFα inhibitor. Immunomodulator. €60.00
3581 ONC212 TRAIL inducer; Selective GPR132 agonist €110.00
2966 NSC745887 DcR3 inhibitor €95.00
1793 Lenalidomide TNFα inhibitor. Immunomodulator. €40.00
2887 DRI-C21045 Inhibitor of the CD40-CD40L costimulatory protein-protein interaction €125.00

10 Item(s)

per page
Please wait...