Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
1621 XMD 8-92 trifluoroacetate BMK1 inhibitor; ERK5 inhibitor €70.00
1846 XMD 8-92 BMK1 inhibitor; ERK5 inhibitor €70.00
1811 VX 745 Inhibitor of p38α MAP kinase €90.00
2520 U 0126 Non-competitive inhibitor of MEK1/2 and protects brain in stroke models €90.00
3183 SR-318 Highly potent and selective type-II p38 α/β inhibitor  Recently added €120.00
2365 SR 3576 Very potent JNK3 inhibitor with >2800-fold selectivity over p38 €135.00
2519 SP 600125 Selective, reversible, and ATP-competitive JNK inhibitor €70.00
1122 SL 327 MEK1 and MEK2 inhibitor €80.00
2956 Selonsertib Potent, highly selective, orally available, and ATP-competitive ASK1 inhibitor €90.00
1357 SD 169 MAPK inhibitor (p38α specific) €60.00
1671 SCIO 469 MAPK inhibitor (p38 specific) €110.00
1897 SB 747651A Inhibitor of MSK1 €120.00
2444 SB 706504 Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes. €125.00
1465 SB 203580 hydrochloride MAPK inhibitor (p38 specific) €70.00
1363 SB 203580 MAPK inhibitor (p38 specific) €95.00

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