Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
3039 ACY-241 Selective and orally available HDAC6 inhibitor  Recently added €120.00
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00
2394 AR-42 HDAC inhibitor €125.00
5052 Axon Ligands™ Epigenetic compound library Axon Ligands™ Epigenetic compound library Inquire
2471 BRD 73954 Dual HDAC 6/8 inhibitor with excellent selectivity over the other HDACs €85.00
2803 Cambinol Inhibitor of SIRT1 and SIRT2 €95.00
2250 CHR 6494 trifluoroacetate Specific, first-in-class inhibitor of histone kinase Haspin €120.00
2014 CI 994 HDAC inhibitor that causes histone hyperacetylation in living cells €70.00
3038 CXD101 HDAC inhibitor (1, 2, 3 Selective)  Recently added €125.00
2568 EML 425 Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) €95.00
2208 Gallic acid Multi-affinity drug. Antioxidant. €50.00
1645 HDAC6 inhibitor ISOX HDAC6 Inhibitor €105.00
2529 JNJ 26481585 dihydrochloride Potent, orally available second-generation pan-HDAC inhibitor €125.00
2319 L 002 Inhibitor of p300 HAT (KAT3B) and p53 acetylation €80.00

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