Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
2445 ZLN 024 Allosteric activator of AMP-activated protein kinase (AMPK) €90.00
2120 Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00
2300 TIC 10 active isomer Small molecule that transcriptionally induces TRAIL €125.00
1875 SRT 1720 tetrahydrochloride Activator of the sirtuin subtype SIRT1 €95.00
2084 SKL 2001 Wnt/β-catenin signaling pathway agonist or activator €90.00
2903 SJ000291942 Activator of the canonical BMP signaling pathway €95.00
2244 SCH 529074 Small molecule activator of mutant p53. €100.00
2507 SC 79 Unique specific activator of cytosolic Akt; neuroprotective €75.00
2666 S-Propargyl-Cysteine Modulator of endogenous hydrogen disulfide €95.00
2497 RTA 408 Triterpenoid activator of NRF2 and inhibitor of NF-κB €110.00
1659 PS 48 Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1) €80.00
2651 OAC2 Oct4 and Nanog activating compound that enhances reprogramming efficiency €60.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction €75.00

Items 1 to 15 of 26 total

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