Wnt-β-Catenin

Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis (embryonic induction, generation of cell polarity, and the specification of cell fate). Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP (low density Lipoprotein Receptor-related Protein) families on the cell surface. The result is alleviation of pathway inhibition caused by GSK-3β, APC, and Axin proteins. This stabilizes β-Catenin and promotes its nuclear translocation where it regulates target gene transcription together with Tcf/Lef proteins. During development, the Wnt/β-catenin pathway integrates signals from many other pathways including Retinoic acid, FGF, TGF-β, and BMP in many different cell-types and tissues. In addition, GSK-3β is also involved in glycogen metabolism and other key pathways, which has made its inhibition relevant to diabetes and neurodegenerative disorders[1],[2].


[1] Wnt signaling and stem cell control. Nusse, R. Cell Research 2008,18, 523-527.
[2] Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors. M. D. Gordon, R. Nusse. J Biol Chem. 2006, 281, 22429-22433.

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Axon ID Name Description From price
5005 Stem Cell LSC inhibitor Set Set of LDN 193189 HCl, SB 431542 and CHIR 99021, inhibitors of BMP, TGF-β, and GSK-3 resp. €145.00
2010 TDZD 8 Selective and non-ATP-competitive inhibitor of GSK-3β €90.00
2339 TH 1834 Tip60 histone acetyltransferase inhibitor €135.00
1854 TTP 22 Inhibitor of Casein kinase 2 (CK2) €105.00
1562 TWS 119 GSK-3β inhibitor €70.00
2188 WAY 262611 dihydrochloride Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist €125.00
2325 WAY 316606 hydrochloride Potent inhibitor of sFRP-1 that stimulates Wnt signaling €85.00
2120 Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00
2287 Wnt-C59 Highly potent porcupine (Porcn) inhibitor €75.00
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00

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