Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis (embryonic induction, generation of cell polarity, and the specification of cell fate). Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP (low density Lipoprotein Receptor-related Protein) families on the cell surface. The result is alleviation of pathway inhibition caused by GSK-3β, APC, and Axin proteins. This stabilizes β-Catenin and promotes its nuclear translocation where it regulates target gene transcription together with Tcf/Lef proteins. During development, the Wnt/β-catenin pathway integrates signals from many other pathways including Retinoic acid, FGF, TGF-β, and BMP in many different cell-types and tissues. In addition, GSK-3β is also involved in glycogen metabolism and other key pathways, which has made its inhibition relevant to diabetes and neurodegenerative disorders[1],[2].

[1] Wnt signaling and stem cell control. Nusse, R. Cell Research 2008,18, 523-527.
[2] Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors. M. D. Gordon, R. Nusse. J Biol Chem. 2006, 281, 22429-22433.

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Axon ID Name Description From price
2212 IWP L6 Highly potent porcupine (Porcn) inhibitor €125.00
2036 KY 02111 Canonical Wnt signaling pathway inhibitor €80.00
2395 KY 05009 Inhibitor of TNIK that attenuates TGF-β1-mediated Wnt and Smad signaling €125.00
2668 KYA1797K Promotor of β-catenin and Ras degradation that effectively suppresses the growth of CRCs €95.00
2325 WAY 316606 hydrochloride Potent inhibitor of sFRP-1 that stimulates Wnt signaling €85.00
2287 Wnt-C59 Highly potent porcupine (Porcn) inhibitor €75.00

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