Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €125.00
2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) €95.00
2699 CCT251236 HSF1 stress pathway inhibitor €145.00
3224 CLK8 CLOCK/BMAL1 interaction inhibitor €160.00
2841 COTI-2 Reactivator of mutant p53 €125.00
1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) €105.00
3412 DTHIB Direct and selective HSF1 inhibitor €90.00
2975 Fatostatin hydrobromide Specific inhibitor of SREBP cleavage-activating protein (SCAP) €90.00
2384 FDI 6 Inhibitor of the Forkhead box protein M1 (FOXM1) €99.00
3457 Fludarabine Inhibitor of DNA synthesis; STAT-1 activation inhibitor  Recently added €50.00
2959 FM19G11 Potent HIFα inhibitor €95.00
2157 FQI 1 Inhibitor of α-globin transcription factor CP2 (LSF) €95.00
2034 HIF-2 inhibitor 2 Allosteric inhibitor of HIF-2 €95.00
2614 HIF-2a Translation Inhibitor 76 HIF-2a translation inhibitor that works independent of mTOR €70.00

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