PI3K-Akt-mTOR

The PI3K/AKT/mTOR signaling pathway is strongly involved in the fundamental cellular processes of protein synthesis and apoptosis, and disturbed activation of this intracellular pathway has been associated with the development of diseases such as cancer, diabetes mellitus, and autoimmunity[1]. Upon activation of  phosphatidylinositol (PI)-3-kinase (PI3K) by extracellular growth factors, phosphorylation of the inner membrane phosphoinositides activates AKT (also known as Protein Kinase B, PKB) and PDPK1 (3-phosphoinositide dependent protein kinase-1). In turn, mTOR (mammalian target of rapamycin)  is activated downstream, which plays an important role in cell cycle progression[2]. In many cancer cells, this PI3K/AKT/mTOR pathway is highly active, which can be the result of  amplification or mutation of the PI3-kinase gene; amplification or mutation of the Akt gene; or loss of function of PTEN (Phosphatase and tensin homolog). The latter normally regulates the removal of phosphate groups of the PI3K mediated phosphorylated membrane phospholipids, one of the regulating mechanisms to prevent over activations of this pathway.


[1] PI3K-Akt pathway: its functions and alterations in human cancer. Osaki M, Oshimura M, Ito H. Apoptosis 2004, 9, 667-676.
[2] PI3K/Akt/mTOR pathway as a target for cancer therapy. D. Morgensztern, H.L. McLeod Drugs 2005, 16, 797–803

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Axon ID Name Description From price
1782 GDC 0980 Dual PI3K and mTOR inhibitor €105.00
2466 Gö 6983 Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ €90.00
2460 GSK 2110183 hydrochloride Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases €105.00
1596 GSK 2126458 Dual PI3K and mTOR inhibitor €80.00
1912 GSK 2636771 dihydrochloride PI3K inhibitor (p110 β specific) €105.00
1729 GSK 690693 ATP-competitive pan-Akt kinase inhibitor €115.00
2021 HL 010183 Metformin derivative; AMPK activator €135.00
2168 IC 87114 Potent and highly selective inhibitor of the PI3K p110δ €85.00
2511 IM 12 GSK-3β inhibitor attenuating neuronal differentiation of human NPCs €95.00
2258 iMDK Specific inhibitor of Midkine (MDK) expression €95.00
2142 INK 128 Potent and selective mTOR inhibitor €110.00
2845 KDU691 PI4K inhibitor €145.00
2604 KU 0060648 DNA-PK inhibitor €125.00
1584 KU 0060648 trihydrochloride DNA-PK inhibitor €95.00
1472 KU 0063794 mTOR inhibitor €60.00

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