PI3K-Akt-mTOR

The PI3K/AKT/mTOR signaling pathway is strongly involved in the fundamental cellular processes of protein synthesis and apoptosis, and disturbed activation of this intracellular pathway has been associated with the development of diseases such as cancer, diabetes mellitus, and autoimmunity[1]. Upon activation of  phosphatidylinositol (PI)-3-kinase (PI3K) by extracellular growth factors, phosphorylation of the inner membrane phosphoinositides activates AKT (also known as Protein Kinase B, PKB) and PDPK1 (3-phosphoinositide dependent protein kinase-1). In turn, mTOR (mammalian target of rapamycin)  is activated downstream, which plays an important role in cell cycle progression[2]. In many cancer cells, this PI3K/AKT/mTOR pathway is highly active, which can be the result of  amplification or mutation of the PI3-kinase gene; amplification or mutation of the Akt gene; or loss of function of PTEN (Phosphatase and tensin homolog). The latter normally regulates the removal of phosphate groups of the PI3K mediated phosphorylated membrane phospholipids, one of the regulating mechanisms to prevent over activations of this pathway.


[1] PI3K-Akt pathway: its functions and alterations in human cancer. Osaki M, Oshimura M, Ito H. Apoptosis 2004, 9, 667-676.
[2] PI3K/Akt/mTOR pathway as a target for cancer therapy. D. Morgensztern, H.L. McLeod Drugs 2005, 16, 797–803

Items 1 to 15 of 56 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
Axon ID Name Description From price
1831 A 66 PI3K inhibitor (p110-α specific) €95.00
2857 Acalisib PI3K inhibitor (p110 δ specific) €120.00
2540 Akt Inhibitor VIII Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) €125.00
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
2748 Autophinib PIK3C3/Vps34 inhibitor €120.00
1859 AZD 5363 dihydrochloride Inhibitor of protein kinase B (Akt) €115.00
1561 AZD 8055 mTOR inhibitor €95.00
1282 BAG 956 PI3K and PDPK1 inhibitor €95.00
1281 BEZ 235 PI3K and mTOR tyrosine kinase inhibitor €60.00
2801 BQR695 PI4K inhibitor €105.00
1390 BX 795 PDPK1, TBK1 and IKK inhibitor €65.00
1130 BX 912 PDPK1 inhibitor €65.00
2170 CAL 101 PI3K inhibitor (p110 δ specific) €95.00
2039 CZC 24832 PI3K inhibitor (p110-γ specific) €95.00

Items 1 to 15 of 56 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
Please wait...