NF-κB

The NF-κB signaling pathway is involved in a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. A remarkable diversity of stimuli lead to the activation of NF-κB, among which are pro-inflammatory cytokines, LPS, growth factors, and antigen receptors. They activate an IKK complex (IKKβ, IKKα, and NEMO), which phosphorylates IκB proteins. Phosphorylation of IκB leads to its ubiquitination and proteasomal degradation, freeing NF-κB/Rel complexes. Active NF-κB/Rel complexes are further activated by phosphorylation and translocate to the nucleus where, either alone or in combination with other transcription factor families including AP-1, Ets, and Stat, they induce target gene expression[1],[2]. The core elements of NF-κB signaling pathways are generally several steps removed from the receptor itself. The intervening steps between receptor and IKK form links to parallel signaling pathways. For example, PKC enzymes play important roles in several signal transduction cascades. In NF-κB signaling, PKC-β connects the B cell receptor to canonical activation of NF-κB through a signaling complex, including Bcl10/MALT1 and NEMO/IKKγ[3].


[1] M.S. Hayden, S. Ghosh. Shared principles in NF-kappaB signaling. Cell. 2008, 132, 344-362.
[2]  Rel/NF-κB Transcription Factors. Gilmore TD. http://www.bu.edu/nf-kb/ 2008.
[3] Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo. G. Lutzny et al. Cancer Cell. 2013, 23, 77-92.

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Axon ID Name Description From price
2208 Gallic acid Multi-affinity drug. Antioxidant. €50.00
2572 GlyH 101 Highly potent and selective CFTR inhibitor €105.00
2466 Gö 6983 Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ €90.00
2582 GSK 137647A Potent and selective FFA4/GPR120 agonist €70.00
2220 GSK 2256294A Potent, reversible, tight binding inhibitor of recombinant human sEH €125.00
2713 GSK 2982772 Specific inhibitor of RIP1 kinase €115.00
3024 GSK'872 Potent and selective RIP3 kinase inhibitor €95.00
2608 GSK481 Potent inhibitor of RIP1 kinase and TNF induced inflammation €95.00
3064 HOIPIN 11a Selective, cell-permeable and covalent inhibitor of RBR E3 ubiquitin ligase HOIP €180.00
2972 HOIPIN-8 Potent linear ubiquitin chain assembly complex (LUBAC) inhibitor €120.00
3217 HS-243 Highly potent and selective IRAK-1/4 inhibitor €90.00
2533 Hydroxypioglitazone Active metabolite of Pioglitazone (M-IV), a PPARγ agonist €235.00
2725 IMD-0354 IKK-2 inhibitor €90.00
2258 iMDK Specific inhibitor of Midkine (MDK) expression €95.00
3107 Imiquimod TLR7/TLR8 agonist €60.00

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