JAK-STAT

JAKs (Janus Kinase; EC 2.7.10.2; 4 types identified) and STATs (Signal Transducer and Activator of Transcription; 7 types identified) are critical components of many cytokine receptor systems, regulating growth, survival, differentiation and pathogen resistance. (Cytokine) receptor-bound STATs phosphorylated by JAKs dimerize and translocate into the nucleus to regulate target gene transcription. In most cases, a specific JAK-STAT combination has been paired with a specific member of the cytokine receptor family, and this information translated into cell-type specific patterns of cytokine responsiveness and gene expression. Members of the suppressor of cytokine signaling (SOCS) protein family dampen receptor signaling via homologous or heterologous feedback regulation[1],[2]. Consequently, Janus kinase mutations are major molecular events in human hematological malignancies[3].


[1] The JAK-STAT Signaling Pathway: Input and Output Integration. P.J. Murray. J. Immunol. 2007, 178, 2623-2629.
[2] A Road Map for Those Who Don't Know JAK-STAT. D.S. Aaronson, C.M. Horvath. Science 2002, 296, 1653-1655.
[3] Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Mol. Immunol. 2007, 44, 2497–506.

15 Item(s)

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Axon ID Name Description From price
1378 AG 490 JAK2 inhibitor €65.00
1778 AZ 960 JAK2 inhibitor €95.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €90.00
1338 CP 690550 JAK3 inhibitor €65.00
1681 CYT 387 JAK1 and JAK2 inhibitor €90.00
1843 JAK2 inhibitor 13 JAK2 inhibitor €105.00
2554 LY 2784544 Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) €95.00
2792 NVP-BSK805 Potent, selective and orally bioavailable JAK2 inhibitor €125.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
1598 Ruxolitinib JAK1 and JAK2 inhibitor €70.00
2539 Solcitinib Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases €90.00
1588 TG 101348 JAK2 inhibitor €95.00
2072 Tofacitinib citrate Potent Janus Kinase 3 (JAK3) inhibitor €115.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2231 XL 019 JAK2 inhibitor €100.00

15 Item(s)

per page
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