JAKs (Janus Kinase; EC; 4 types identified) and STATs (Signal Transducer and Activator of Transcription; 7 types identified) are critical components of many cytokine receptor systems, regulating growth, survival, differentiation and pathogen resistance. (Cytokine) receptor-bound STATs phosphorylated by JAKs dimerize and translocate into the nucleus to regulate target gene transcription. In most cases, a specific JAK-STAT combination has been paired with a specific member of the cytokine receptor family, and this information translated into cell-type specific patterns of cytokine responsiveness and gene expression. Members of the suppressor of cytokine signaling (SOCS) protein family dampen receptor signaling via homologous or heterologous feedback regulation[1],[2]. Consequently, Janus kinase mutations are major molecular events in human hematological malignancies[3].

[1] The JAK-STAT Signaling Pathway: Input and Output Integration. P.J. Murray. J. Immunol. 2007, 178, 2623-2629.
[2] A Road Map for Those Who Don't Know JAK-STAT. D.S. Aaronson, C.M. Horvath. Science 2002, 296, 1653-1655.
[3] Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Mol. Immunol. 2007, 44, 2497–506.

3 Item(s)

per page
Axon ID Name Description From price
2455 CU-T12-9 Selective TLR1/TLR2 agonist that facilitates the TLR1/2 complex formation €120.00
2318 FC 99 hydrochloride Inhibitor of TLR3 expression and inflammatory responses. €95.00
2999 RCGD 423 gp130 signalling modulator  Recently added €125.00

3 Item(s)

per page
Please wait...