Research Areas
In this section, by far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 4114 | (±)-trans-ML-SI3 | TRPML1/3 inhibitor and TRPML2 activator | Recently added | €120.00 |
| 1816 | A 784168 | TRPV1 receptor antagonist | €95.00 | |
| 2182 | A 804598 | Potent and selective P2X7 antagonist | €125.00 | |
| 3835 | A-438079 hydrochloride | Competitive P2X7 antagonist | €110.00 | |
| 1504 | ABT 102 | TRPV1 antagonist | €90.00 | |
| 3356 | AMG 9810 | Potent and selective vanilloid receptor-1 (TRPV1) antagonist | €90.00 | |
| 3845 | BAY-1797 | Potent and selective P2X4 inhibitor | €130.00 | |
| 2523 | BX 430 | Allosteric antagonist of human P2X4 receptor channels | €105.00 | |
| 2742 | GSK 2193874 | Orally active TRPV4 antagonist | €120.00 | |
| 1967 | GW 791343 hydrochloride | P2X7 receptor antagonist and allosteric modulator | Inquire | |
| 3262 | HEI3090 | Positive modulator of the P2X7 receptor | €130.00 | |
| 3429 | Indophagolin | Potent autophagy inhibitor | €130.00 | |
| 2890 | JNJ 47965567 | Potent, brain-penetrant P2X7 antagonist | €130.00 | |
| 2423 | M8-B hydrochloride | Selective and potent antagonist of the TRPM8 channel | €115.00 | |
| 4193 | ML-SA1 | Potent and specific TRPML1 agonist | Recently added | €90.00 |
| 2980 | ML2-SA1 | Potent and selective activator of TRPML2 | €105.00 | |
| 3633 | Ononetin | Potent and selective TRPM3 antagonist | €60.00 | |
| 2374 | Optovin | Reversible photoactivated TRPA1 agonist | €85.00 | |
| 2483 | PF 05105679 | TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans | €95.00 | |
| 2498 | RQ 00203078 | Selective, potent, and orally active TRPM8 antagonist with in vivo activity | €125.00 | |
| 3287 | SET2 | Potent and selective TRPV2 inhibitor | €100.00 | |
| 4100 | TRPML3 activator SN2 | First selective TRPML3 activator | €105.00 | |
| 4226 | TRPV1 antagonist CX-3 | First-in-class highly selective TRPV1 antagonist | €90.00 | |