Research Areas
In this section, by far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2212 | IWP L6 | Highly potent porcupine (Porcn) inhibitor | €130.00 | |
| 2036 | KY 02111 | Canonical Wnt signaling pathway inhibitor | €80.00 | |
| 2395 | KY 05009 | Inhibitor of TNIK that attenuates TGF-β1-mediated Wnt and Smad signaling | €125.00 | |
| 2668 | KYA1797K | Promotor of β-catenin and Ras degradation that effectively suppresses the growth of CRCs | €95.00 | |
| 2325 | WAY 316606 hydrochloride | Potent inhibitor of sFRP-1 that stimulates Wnt signaling | €85.00 | |
| 2287 | Wnt-C59 | Highly potent porcupine (Porcn) inhibitor | €75.00 | |
| 3206 | YW2065 | Inhibitor of Wnt/β-catenin signalling; AMPK activator | €95.00 | |
Categories
- Filter by Action
- Filter by Endogenous Substrate
- (Nor-)Adrenaline (2)
- (S)-Mandelate (1)
- (S)-Palmitoylated proteins (1)
- 2-Arachidonoyl glycerol (2-AG) (5)
- 3-Phosphoglycerate (2)
- 4-Hydroxyphenylpyruvate (1)
- Abscisic acid (2)
- Acetylcholine (41)
- Ack1-AR-ATM signaling (3)
- Adenosine (28)
- Adiponectin (1)
- ADP (1)
- Adrenaline, (Nor-) (2)
- AGE (1)
- Aggrecan (1)
- AKT/GSK-3β/Snail signaling (1)
- Alcohol (5)
- Aldose (3)
- Ammonia; Urea (1)
- AMP (1)
- Amyloids (18)
- Androgen Receptor (AR) (1)
- Androgenic Hormones (6)
- Androgenic hormones (5)
- Androgenic Hormones;Estrogen (1)
- Androstane (2)
- Angiotensin (14)
- Anthelmintic (2)
- Antibiotic (14)
- Antifungal (7)
- Antigen (1)
- Antioxidant (8)
- AP2 (2)
- Apelin (1)
- APP (1)
- ATP (23)
- Atrial natriuretic peptide (ANP) (1)
- Autophagy (2)
- Auxin (2)
- B-Cell Transformation (8)
- B-Cell transformation (3)
- BCAA (1)
- Biliary System (1)
- Building Blocks (2)
- C-Nap1;PP1;Nek2 (1)
- Calcitriol (3)
- Calcium (37)
- Calcium;Potassium;Sodium (2)
- cAMP (25)
- Cannabinoids (30)
- Carbondioxide (3)
- Caspase (8)
- Catecholamines (2)
- Cation-Cl− cotransporters (CCCs) (1)
- Cell Cycle Regulation (2)
- Cellular Metabolic Homeostasis (3)
- Ceramide (1)
- cGMP (8)
- CGRP (1)
- Chemokine (18)
- Chenodeoxycholic acid (4)
- Chitin (2)
- Chloride (9)
- Cholecystokinin (1)
- Cholesterol (3)
- Choline (2)
- Choline-based esters (1)
- Chromatin (2)
- Citric acid (2)
- Coagulation (2)
- Coenzyme Q (CoQ) biosynthesis (1)
- Collagen (1)
- Corticotropin Releasing Hormone (3)
- Cortisone (2)
- Cyclic 2'3'- cGAMP (1)
- Cyclin dependent (CDK) (6)
- Cyclin Dependent (CDK) (20)
- Cyclopamine (7)
- Cysteine residues (3)
- Cysteinyl leukotrienes (3)
- Cytoskeleton (35)
- D-Luciferin (2)
- Decaprenylphosphoryl-beta-D-ribofuranose (DPR) (2)
- Dehydroepiandrosterone;Androstenedione (1)
- Deoxyuridine monophosphate (dUMP) (4)
- Diacylglycerol (4)
- Dihydrofolic acid (1)
- Dihydroorotate (2)
- DNA (10)
- DNA-CDN (8)
- DNA-damage response (5)
- DNA-RNA (205)
- dNTP (oxidized) (4)
- Dopamine (76)
- Dopamine;Norepinephrine;Serotonin (1)
- ECM-adhesion (15)
- EGF (18)
- EGF-VEGF (2)
- Eicosanoid epoxides (3)
- Endothelin (2)
- Endothelin;Non Selective (2)
- Ephrins (1)
- Estrogen (24)
- Estrogen, Unfolded Protein Response (Non Selective) (2)
- Farnesyl substrates (CaaX motif) (1)
- Fatty acid (Amides) (4)
- Fatty acid (Arachidonic acid) (22)
- Fatty acid (Linoleic acid) (1)
- Fatty acid (Stearic acid) (1)
- Fatty acids (3)
- FFA (8)
- FGF (10)
- FGF-VEGF (2)
- FLT3LG (4)
- Free radical scavenger (2)
- Fructose 6-phosphate (4)
- G-Proteins (1)
- GABA (24)
- Gas6 (3)
- GDNF (4)
- Geranyl Diphosphate (1)
- GLP1 (3)
- Glucagon (1)
- Glucocorticoid (15)
- Gluconeogenesis (1)
- Glucose (10)
- Glucose Homeostasis (4)
- Glutamate (62)
- Glutamate oxaloacetate (1)
- Glutamine (3)
- Glutathion (GSH) (1)
- Glutathione disulfide,Thioredoxin (1)
- Glycans (1)
- Glyceraldehyde 3-phosphate (1)
- Glycine (4)
- Glycogen (1)
- Glycosides (6)
- GnRH (1)
- Golgi apparatus (1)
- gp120 (1)
- GPCR-independent noncanonical G-protein signaling (1)
- GTP (20)
- Hedgehog (4)
- Hemoglobin (2)
- HGF (14)
- HGF-VEGF (2)
- Hippo signaling pathway (3)
- Histamine (29)
- Histidine,Oligopeptide (2)
- Histone (131)
- HMG-CoA (3)
- Hydrogen peroxide,Chloride (1)
- Hypoxanthine (2)
- Hypoxia-signaling cascade (8)
- iC3b/C4b (1)
- IGF1 (5)
- IGF2 (1)
- Imidazoline (2)
- Immunology (7)
- Innate immune system (2)
- Inosine monophosphate (IMP) (2)
- Inositol hexakisphosphate (InsP6) (1)
- Inositol-1,4,5-trisphosphate (InsP3) (2)
- Interleukin (13)
- Intracellular transcription factors (1)
- Intracellular Transcription Factors (3)
- Iron (III) (2)
- Isocitrate (6)
- IκB (9)
- JAK-STAT Pathway (22)
- Kinins (3)
- L-Alanine;L-Serine;L-Cysteine (1)
- L-Arginine (4)
- L-Cysteine (1)
- L-Kynurenine (10)
- L-Lactate,L-Phenylalanine (1)
- Lactate (2)
- Lands cycle (1)
- LCCs;RyRs;PLB (3)
- Lipid A precursor (3)
- LPA (3)
- LPC (4)
- LRP5 (1)
- Mannosidose (α form) (1)
- MAPK (62)
- MEK (17)
- Melanin Concentrating Hormone (1)
- Melatonin (5)
- Metabolism (27)
- Methionine (1)
- MHC class II,FGL1 (1)
- Microtubules (7)
- Mineralocorticoid (1)
- Mitochondrial protein import (1)
- Mono-amines (12)
- Monocarboxylates (2)
- NADH (3)
- NADP+ (1)
- NADPH (2)
- Natural product (21)
- NEDD8 (1)
- Neryl Diphosphate (1)
- Neuropeptide S (1)
- Neuropeptide Y (1)
- Neurotensin (3)
- Neurotrophin (9)
- NF-κB pathway (5)
- NF-κB Pathway (7)
- Nicotinamide D-ribonucleotide (5)
- Nicotinamide riboside kinase (1)
- Nicotinic acid (1)
- NMNAT (1)
- Non Selective (110)
- Non Selective (ADF-cofilin) (4)
- Non Selective (Aldehydes) (1)
- Non Selective (Aldehydes; Carboxylic acids) (1)
- Non Selective (Anions) (3)
- Non Selective (Arginine Sites Proteins) (10)
- Non Selective (Arginine sites proteins) (5)
- Non Selective (Aspartate Peptide Bonds) (6)
- Non Selective (Cations) (22)
- Non Selective (CHK2,p53) (2)
- Non Selective (CHK2; p53) (8)
- Non Selective (CHK2;p53) (1)
- Non Selective (COX substrates; Cannabinoids) (1)
- Non Selective (Cysteine Peptide Bonds) (4)
- Non Selective (Cysteine Peptide Bonds); Dopamine; Adrenaline, (Nor-) (1)
- Non Selective (Glucocorticoid) (2)
- Non Selective (Glutathione) (1)
- Non Selective (Glycans; Malondialdehyde) (1)
- Non Selective (glycosyl donors) (1)
- Non Selective (Histone; Survivin; Topo) (3)
- Non Selective (Histone; Survivin; Topo; TPX2) (5)
- Non Selective (Histone; Survivin; Topo; TPX2); JAK-STAT Pathway; Non Selective (Phosphorylation Substrates) (1)
- Non Selective (Ions; Na+Ca2+) (2)
- Non Selective (Ions; Na+H+) (1)
- Non Selective (LIM; p53; TPX2) (5)
- Non Selective (LIM;p53;TPX2) (3)
- Non Selective (Lysine Sites Proteins) (1)
- Non Selective (Membranes) (1)
- Non Selective (Methionine Peptide Bonds) (1)
- Non Selective (Mitotic spindle checkpoint) (1)
- Non Selective (Mitotic Spindle Checkpoint) (4)
- Non Selective (Neurotensin and Dopamine) (1)
- Non Selective (Noradrenaline; Dopamine) (1)
- Non Selective (Phosphorylation substrates) (17)
- Non Selective (Phosphorylation Substrates) (106)
- Non Selective (Phosphorylation Substrates); MAPK (1)
- Non Selective (Phosphorylation Substrates); MAPK; FGF-VEGF (1)
- Non Selective (Proline Peptide Bonds) (9)
- Non Selective (Proteins) (2)
- Non Selective (Ribosomal proteins) (9)
- Non Selective (Serine Peptide Bonds) (14)
- Non Selective (Serine peptide bonds) (4)
- Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) (9)
- Non Selective (Serine-Threonine;Tyrosine Specific Phosphodiesters) (1)
- Non Selective (Serotonin; Noradrenaline) (12)
- Non Selective (Thiols) (2)
- Non Selective (Tripeptides) (1)
- Non Selective (Tyrosine specific phosphomonoesters) (5)
- Non Selective (Tyrosine Specific Phosphomonoesters) (14)
- Non Selective (Ubiquitin peptides) (39)
- NotchΔE-eGFP (1)
- Odor molecule (1)
- Oligosaccharide (1)
- Opioids (18)
- Orexin (5)
- Ornithine (1)
- Oxidative stress (1)
- Oxygen (1)
- Oxysterols (2)
- Oxytocin (2)
- p-Hydroxyphenyl-pyruvate (HPP),Phenylpyruvate (1)
- p-Hydroxyphenyl-pyruvate (HPP);Phenylpyruvate (1)
- p-tyramine; b-phenethylamine; octopamine; tryptamine (1)
- p53 (16)
- Palmitoyl-CoA; L-serine (1)
- PDGF (1)
- PDGF-FGF-VEGF (2)
- Peptides (Endoplasmatic reticulum) (1)
- Phosphatidylcholine (2)
- Phosphatidylinositol (100)
- Phosphatidylinositol 5-phosphate (PI-5-P) (1)
- Phospholipid metabolism (1)
- Phospholipids (5)
- phosphorylated Ampk α (pAmpkα) (1)
- Plasminogen (1)
- Potassium (50)
- PP2A (1)
- PPAR-γ (1)
- Progesterone (7)
- Prostaglandins (21)
- Protein degradation (7)
- Protein Disulfide Isomerase (PDI) (1)
- Protein L-arginine (1)
- Protein Rad21 (1)
- Proton (1)
- Proton-sensing (1)
- Pyruvate (4)
- Quinol (1)
- Quorum Sensing (1)
- RAS proteins (7)
- Redox (1)
- Retinoic acid (2)
- Retinoic Acid (14)
- Retrograde trafficking (1)
- Ribosome rescue (2)
- RLR pathway (2)
- RNA (2)
- S-adenosylmethionine (1)
- S-nitrosoglutathione (1)
- S-palmitoylated proteins (1)
- SCF-FLT3-PDGF (2)
- SCF-PDGF-FGF (1)
- SCF-PDGF-VEGF (7)
- SCF-VEGF (2)
- Securin,B type cyclins (1)
- Serotonin (104)
- Serotonin; Dopamine (32)
- Serpin (9)
- Sigma Receptor Substrates (6)
- Sigma receptor substrates; Serotonin (1)
- SIPA (1)
- Smad (3)
- Sodium (11)
- Somatostatin (4)
- Sonic Hedgehog (2)
- Sphingolipid (2)
- Sphingosine (5)
- Sphingosine-1-phosphate (8)
- Stem cells (iPSC) (5)
- Steroid (Androgens) (4)
- Steroid (Lanosterol 14-α) (5)
- Steroids (2)
- Succinate (1)
- Succinic acid (1)
- Superoxide (1)
- Synaptic Vesicle Glycoprotein Substrates (3)
- T-Cell activity (3)
- T-Cell signaling (1)
- T3 (1)
- Tachykinin (6)
- Tachykinin (1)
- TGF-β (27)
- Thrombin (9)
- Thrombopoietin (1)
- Thymidylate pathway (2)
- Thyroid-stimulating hormone (thyrotropin) (1)
- TNF-α (10)
- Transthyretin (1)
- Triglycerides (10)
- Triiodothyronine (2)
- Ubiquitin (3)
- UDP (1)
- UDP-glucose (3)
- Unclassified (15)
- Unfolded Protein Response (EIF2 Selective) (3)
- Unfolded protein response (EIF2 selective) (1)
- Unfolded Protein Response (Non Selective) (11)
- Unfolded protein response (Non selective) (2)
- Uric acid (2)
- Vasopressin (5)
- VEGF (14)
- Viral hemagglutinin (1)
- VLA-4 (1)
- Water (4)
- Wnt proteins
- Xanthine (1)
- Zinc (1)
- α-Synuclein (1)
- β-Lactams (3)