Research Areas
In this section, by far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1810 | Bortezomib | Inhibitor of 26S proteasome | €80.00 | |
| 2935 | COH000 | First-in-class, highly specific, covalent allosteric inhibitor of SUMO E1 | €175.00 | |
| 3709 | DKM 2-93 | Selective inhibitor of UBA5 | €70.00 | |
| 1798 | Eeyarestatin I | Inhibitor of endoplasmic reticulum associated protein degradation (ERAD) | €80.00 | |
| 3732 | HBX 41,108 | Inhibitor of deubiquitinase USP7 | €110.00 | |
| 3426 | IU1-47 | Potent and selective inhibitor deubiquitinase USP14 | €80.00 | |
| 3770 | KSQ-2479 | An allosteric, first-in-class USP1 (Ubiquitin Specific Protease 1) inhibitor | Inquire | |
| 2449 | LDN 57444 | Reversible, competitive inhibitor of UCH-L1 deubiquitinase | €95.00 | |
| 3724 | M-3258 | Selective inhibitor of LMP7 subunit of the immunoproteasome | Inquire | |
| 1869 | MG 132 | Inhibitor of 26S proteasome | €80.00 | |
| 2309 | ML 323 | Selective, reversible and potent inhibitor of the USP1–UAF1 deubiquitinase complex | €95.00 | |
| 2995 | ML 367 | Inhibitor of ATAD5 stabilization | €125.00 | |
| 3109 | ML-792 | Potent and selective inhibitor of SUMO-activating enzyme (SAE) | €145.00 | |
| 2678 | ML364 | Inhibitor of the deubiquitinase USP2 | €125.00 | |
| 2556 | MLN 2238 | Selective and reversible 20S proteasome inhibitor | €85.00 | |
| 2557 | MLN 9708 | Citrate prodrug of MLN 2238, selective and reversible 20S proteasome inhibitor | €95.00 | |
| 3829 | MLN7243 | Cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes) | Inquire | |
| 2565 | N106 | Activator of E1 ligase mediated SERCA2a SUMOylation | €95.00 | |
| 2228 | NSC 687852 | Inhibitor of 19S regulatory-particle–associated deubiquitinases (DUBs: UCHL5 and USP14) | €90.00 | |
| 2199 | ONX 0914 | Selective inhibitor of LMP7 subunit of the immunoproteasome. | €70.00 | |
| 3849 | Oprozomib | Orally active and irreversible inhibitor of 20S proteasome | Inquire | |
| 2011 | P 005091 | Inhibitor of deubiquitinase USP7 and USP47 | €95.00 | |
| 1906 | P 22077 | Inhibitor of deubiquitinase USP7 and USP47 | €95.00 | |
| 1953 | PRT 4165 | E3 Ubiquitin ligase Bmi1/Ring1A inhibitor | €70.00 | |
| 3210 | RA375 | Potent RPN13 inhibitor | Recently added | €180.00 |
| 1904 | SMER 3 | Inhibitor of an SCF family E3 Ubiquitin ligase | €90.00 | |
| 2512 | Spautin 1 | Inhibitor of USP10 and USP13 and Beclin1 related autophagy | €95.00 | |
| 3608 | STD1T | Inhibitor of the deubiquitinase USP2a | €160.00 | |
| 3797 | TAK-981 oxalate | Inhibitor of SUMOylation | €110.00 | |
| 2333 | TCID | Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1 | €80.00 | |