Research Areas
In this section, by far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2467 | (+)-ITD-1 | Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis | €165.00 | |
| 1744 | A 77-01 | TGF-βR 1 inhibitor; ALK 5 inhibitor | €80.00 | |
| 1421 | A 83-01 | TGF-βR 1 inhibitor; ALK 5 inhibitor | €70.00 | |
| 4168 | BMS-986260 | Potent, selective and orally bioavailable TGF-βR 1 inhibitor | €120.00 | |
| 3914 | CDD-1653 | First-in-class, highly potent, and selective BMPR2 kinase inhibitor | €110.00 | |
| 1708 | Dorsomorphin | Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 | €65.00 | |
| 2150 | Dorsomorphin dihydrochloride | Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 | €65.00 | |
| 1832 | GW 788388 | TGF-βR 1 inhibitor | €50.00 | |
| 2236 | IN 1130 | TGF-βR 1 inhibitor | €95.00 | |
| 2323 | ITD 1 | Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis | €105.00 | |
| 2189 | K 02288 | Inhibitor of BMP signaling. Inhibits ALK1, 2, and 6 | €90.00 | |
| 1509 | LDN 193189 hydrochloride | Highly potent small molecule inhibitor of BMP type I receptors ALK2, ALK3, and ALK6 | €65.00 | |
| 3552 | LDN 212854 | Potent ALK2-biased BMP type I receptor kinase inhibitor | €110.00 | |
| 2201 | LDN 212854 trihydrochloride | Potent ALK2-biased BMP type I receptor kinase inhibitor | €110.00 | |
| 1491 | LY 2157299 | TGF-βR2 inhibitor | €60.00 | |
| 3892 | LY-3200882 | TGF-βR 1 inhibitor | Inquire | |
| 3404 | LY-364947 | Potent, selective and ATP-competitive TGF-βR 1 inhibitor | €90.00 | |
| 1661 | SB 431542 | TGF-βR1 inhibitor; ALK inhibitor | €70.00 | |
| 2197 | SB 505124 | Selective inhibitor of TGF-β type I receptors ALK4 and ALK5 | €95.00 | |
| 2285 | SB 525334 | Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor | €105.00 | |
| 4165 | SB4 | Potent BMP agonist | €80.00 | |
| 1387 | SD 208 | TGF-βR 1 inhibitor | €50.00 | |
| 2903 | SJ000291942 | Activator of the canonical BMP signaling pathway | €95.00 | |
| 2943 | SRI-011381 hydrochloride | TGF-β signaling agonist | €125.00 | |
| 5004 | Stem Cell LSB inhibitor Set | Set of BMP inhibitor LDN 193189 (Axon 1509) and TGF-β inhibitor SB 431542 (Axon 1661) | €90.00 | |
| 5005 | Stem Cell LSC inhibitor Set | Set of LDN 193189 HCl, SB 431542 and CHIR99021, inhibitors of BMP, TGF-β, and GSK-3 resp. | €130.00 | |
| 3076 | TJ191 | Potent and selective anti-cancer agent targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells | €120.00 | |