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Research Areas

In ths section, by  far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.

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Axon ID Name Description From price
1621 XMD 8-92 trifluoroacetate BMK1 inhibitor; ERK5 inhibitor €70.00
1846 XMD 8-92 BMK1 inhibitor; ERK5 inhibitor €70.00
1811 VX 745 Inhibitor of p38α MAP kinase €90.00
2520 U 0126 Non-competitive inhibitor of MEK1/2 and protects brain in stroke models €90.00
3282 Takinib Potent and selective TAK1 (MAP3K7) inhibitor  Recently added €105.00
3183 SR-318 Highly potent and selective type-II p38 α/β inhibitor €120.00
2365 SR 3576 Very potent JNK3 inhibitor with >2800-fold selectivity over p38 €135.00
2519 SP 600125 Selective, reversible, and ATP-competitive JNK inhibitor €70.00
1122 SL 327 MEK1 and MEK2 inhibitor €80.00
2956 Selonsertib Potent, highly selective, orally available, and ATP-competitive ASK1 inhibitor €90.00
1357 SD 169 MAPK inhibitor (p38α specific) €60.00
1671 SCIO 469 MAPK inhibitor (p38 specific) €110.00
1897 SB 747651A Inhibitor of MSK1 €120.00
2444 SB 706504 Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes. €125.00
1465 SB 203580 hydrochloride MAPK inhibitor (p38 specific) €70.00

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Categories
  1. Angiogenesis
  2. Apoptosis
  3. CNS
  4. Cardiovascular
  5. Cell Cycle Regulation
  6. Cell Signaling & Oncology
  7. Diabetes & Metabolism
  8. Endocrinology
  9. Epigenetics
  10. Immunology
  11. Pain & Inflammation
  12. Stem Cell
  13. Miscellaneous
Filter by Endogenous Substrate
  1. 2-arachidonoyl glycerol (2-AG) (5)
  2. 3-phosphoglycerate (2)
  3. Acetylcholine (2)
  4. Ack1-AR-ATM signaling (3)
  5. Adenosine (1)
  6. ADP (1)
  7. Adrenaline, (Nor-) (3)
  8. AGE (1)
  9. Aggrecan (1)
  10. Alcohol (1)
  11. Aldose (2)
  12. Amyloids (13)
  13. Antigen (1)
  14. AP2 (2)
  15. Arginine (1)
  16. Arginine, L- (1)
  17. ATP (15)
  18. B-Cell Transformation (7)
  19. BCAA (1)
  20. C-Nap1,PP1,Nek2 (1)
  21. Calcium (2)
  22. cAMP (17)
  23. Carbondioxide (2)
  24. Caspase (4)
  25. Cation-Cl− cotransporters (CCCs) (1)
  26. CDK1 (1)
  27. Cell Cycle Regulation (1)
  28. Cellular Metabolic Homeostasis (1)
  29. Ceramide (1)
  30. cGMP (6)
  31. Chloride (3)
  32. Cholesterol (1)
  33. Choline (2)
  34. Citric acid (1)
  35. Collagen (1)
  36. Cortisone (1)
  37. Cyclin Dependent (CDK) (14)
  38. Cytoskeleton (25)
  39. Decaprenylphosphoryl-beta-D-ribofuranose (DPR) (2)
  40. Dehydroepiandrosterone,Androstenedione (1)
  41. Deoxyuridine monophosphate (dUMP) (2)
  42. Diacylglycerol (1)
  43. Dihydroorotate (2)
  44. DNA (3)
  45. DNA-damage response (5)
  46. DNA-RNA (122)
  47. dNTP (oxidized) (4)
  48. Dopamine (2)
  49. ECM-adhesion (7)
  50. EGF (14)
  51. EGF-VEGF (2)
  52. Eicosanoid epoxides (3)
  53. Endothelin; Non Selective (1)
  54. Ephrins (1)
  55. Farnesyl substrates (CaaX motif) (1)
  56. Fatty acid (Amides) (2)
  57. Fatty acid (Arachidonic acid) (13)
  58. Fatty acid (Linoleic acid) (1)
  59. Fatty acid (Stearic acid) (1)
  60. Fatty acids (3)
  61. FGF (9)
  62. FGF-VEGF (2)
  63. FLT3LG (4)
  64. Fructose 6-phosphate (2)
  65. G-Proteins (1)
  66. Gas6 (3)
  67. GDNF (2)
  68. Gluconeogenesis (1)
  69. Glucose (5)
  70. Glutathion (GSH) (1)
  71. Glycans (1)
  72. Glycine (3)
  73. Glycogen (1)
  74. Glycosides (3)
  75. Golgi apparatus (1)
  76. GTP (8)
  77. Hedgehog (2)
  78. Hemoglobin (2)
  79. HGF (8)
  80. HGF-VEGF (2)
  81. Histone (84)
  82. HMG-CoA (1)
  83. Hypoxanthine (2)
  84. Hypoxia-signaling cascade (7)
  85. IGF1 (3)
  86. Innate immune system (1)
  87. Interleukin (6)
  88. Interleukin-8 (1)
  89. Isocitrate (4)
  90. IκB (7)
  91. JAK-STAT Pathway (15)
  92. Kinins (3)
  93. Kynurenine, L- (8)
  94. Lactate (1)
  95. LCCs, RyRs, and PLB (2)
  96. Lipid A precursor (3)
  97. LPC (1)
  98. LRP5 (1)
  99. Mannosidose (α form) (1)
  100. MAPK
  101. MEK (12)
  102. Microtubules (6)
  103. Mono-amines (11)
  104. NADH (1)
  105. NADP+ (1)
  106. NADPH (2)
  107. NEDD8 (1)
  108. Neurotrophin (4)
  109. NF-κB Pathway (6)
  110. Nicotinamide D-ribonucleotide (3)
  111. Non Selective (49)
  112. Non Selective (ADF-cofilin) (4)
  113. Non Selective (Anions) (1)
  114. Non Selective (Arginine Sites Proteins) (8)
  115. Non Selective (Aspartate Peptide Bonds) (6)
  116. Non Selective (CHK2; p53) (8)
  117. Non Selective (COX substrates; Cannabinoids) (1)
  118. Non Selective (Cysteine Peptide Bonds) (3)
  119. Non Selective (Glucocorticoid) (1)
  120. Non Selective (glycosyl donors) (1)
  121. Non Selective (Histone; Survivin; Topo) (3)
  122. Non Selective (Histone; Survivin; Topo; TPX2) (5)
  123. Non Selective (Histone; Survivin; Topo; TPX2); JAK-STAT Pathway; Non Selective (Phosphorylation Substrates) (1)
  124. Non Selective (Ions; Na+Ca2+) (1)
  125. Non Selective (Ions; Na+H+) (1)
  126. Non Selective (LIM; p53; TPX2) (4)
  127. Non Selective (Lysine Sites Proteins) (1)
  128. Non Selective (Methionine Peptide Bonds) (1)
  129. Non Selective (Mitotic Spindle Checkpoint) (4)
  130. Non Selective (Noradrenaline; Dopamine) (1)
  131. Non Selective (Phosphorylation Substrates) (92)
  132. Non Selective (Phosphorylation Substrates); MAPK (1)
  133. Non Selective (Phosphorylation Substrates); MAPK; FGF-VEGF (1)
  134. Non Selective (Proline Peptide Bonds) (5)
  135. Non Selective (Ribosomal proteins) (5)
  136. Non Selective (Serine Peptide Bonds) (12)
  137. Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) (7)
  138. Non Selective (Serotonin; Noradrenaline) (10)
  139. Non Selective (Tripeptides) (1)
  140. Non Selective (Tyrosine Specific Phosphomonoesters) (8)
  141. Non Selective (Ubiquitin peptides) (22)
  142. NotchΔE-eGFP (1)
  143. p-Hydroxyphenyl-pyruvate (HPP),Phenylpyruvate (1)
  144. p53 (11)
  145. Palmitoyl-CoA; L-serine (1)
  146. PDGF-FGF-VEGF (2)
  147. Phosphatidylcholine (2)
  148. Phosphatidylinositol (67)
  149. Phospholipids (3)
  150. Potassium (5)
  151. PP2A (1)
  152. Prostaglandins (1)
  153. Protein Disulfide Isomerase (PDI) (1)
  154. Protein Rad21 (1)
  155. Pyruvate (2)
  156. Quorum Sensing (1)
  157. RAS proteins (3)
  158. Retrograde trafficking (1)
  159. Ribosome rescue (2)
  160. S-nitrosoglutathione (1)
  161. S-palmitoylated proteins (1)
  162. SCF-FLT3-PDGF (2)
  163. SCF-PDGF-FGF (1)
  164. SCF-PDGF-VEGF (6)
  165. SCF-VEGF (2)
  166. Securin,B type cyclins (1)
  167. Serotonin (7)
  168. Serpin (5)
  169. SIPA (1)
  170. Smad (2)
  171. Sonic Hedgehog (2)
  172. Sphingosine (4)
  173. Stem cells (iPSC) (1)
  174. Steroid (Androgens) (2)
  175. Steroid (Lanosterol 14-α) (4)
  176. Steroids (2)
  177. Succinic acid (1)
  178. Superoxide (1)
  179. T-Cell activity (1)
  180. T-Cell signaling (1)
  181. TGF-β (3)
  182. Thrombin (1)
  183. Thymidylate pathway (1)
  184. TNF-α (6)
  185. Triglycerides (8)
  186. Unfolded Protein Response (EIF2 Selective) (3)
  187. Unfolded Protein Response (Non Selective) (6)
  188. Uric acid (2)
  189. VEGF (12)
  190. Water (3)
  191. Wnt proteins (7)
  192. Xanthine (1)
  193. Zinc (1)
  194. β-Lactams (1)
Filter by Action
  1. Activator (1)
  2. Inhibitor
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