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Research Areas

In ths section, by  far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.

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Axon ID Name Description From price
2830 (R)-CE3F4 Potent inhibitor of EPAC1 €105.00
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
2989 15-LOX-1 inhibitor i472 Inhibitor of 15-lipoxygenase-1 (15-LOX-1) €165.00
2175 3PO Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. €65.00
1902 4μ8C IRE1α inhibitor €105.00
2125 6,8-Bis(benzylthio)octanoic acid Inhibitor of mitochondrial pyruvate dehydrogenase (PDH) complex €105.00
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
1666 A 357300 hydrochloride MetAP2 inhibitor €95.00
1831 A 66 PI3K inhibitor (p110-α specific) €95.00
1698 A 770041 Orally active src-family selective lck inhibitor €135.00
2059 A 922500 Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor €105.00
2705 A-196 Potent and selective inhibitor of SUV4-20 €105.00
2720 A-92 Inhibitor of GCN2 (EIF2AK4) €145.00
3019 A2764 dihydrochloride Selective inhibitor of the TRESK potassium channel €105.00
3060 A2793 Inhibitor of the TRESK and TASK-1 potassium channel €95.00

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Categories
  1. Angiogenesis
  2. Apoptosis
  3. CNS
  4. Cardiovascular
  5. Cell Cycle Regulation
  6. Cell Signaling & Oncology
  7. Diabetes & Metabolism
  8. Endocrinology
  9. Epigenetics
  10. Immunology
  11. Pain & Inflammation
  12. Stem Cell
  13. Miscellaneous
Filter by Endogenous Substrate
  1. 2-arachidonoyl glycerol (2-AG) (5)
  2. 3-phosphoglycerate (2)
  3. Acetylcholine (1)
  4. Ack1-AR-ATM signaling (3)
  5. Adenosine (1)
  6. ADP (1)
  7. Adrenaline, (Nor-) (3)
  8. AGE (1)
  9. Aggrecan (1)
  10. Alcohol (1)
  11. Aldose (2)
  12. Amyloids (13)
  13. Antigen (1)
  14. AP2 (2)
  15. Arginine (1)
  16. Arginine, L- (1)
  17. ATP (14)
  18. B-Cell Transformation (7)
  19. BCAA (1)
  20. C-Nap1,PP1,Nek2 (1)
  21. Calcium (2)
  22. cAMP (15)
  23. Carbondioxide (2)
  24. Caspase (3)
  25. Cation-Cl− cotransporters (CCCs) (1)
  26. CDK1 (1)
  27. Cell Cycle Regulation (1)
  28. Cellular Metabolic Homeostasis (1)
  29. Ceramide (1)
  30. cGMP (6)
  31. Chloride (3)
  32. Cholesterol (1)
  33. Choline (2)
  34. Citric acid (1)
  35. Collagen (1)
  36. Cortisone (1)
  37. Cyclin Dependent (CDK) (12)
  38. Cytoskeleton (24)
  39. Decaprenylphosphoryl-beta-D-ribofuranose (DPR) (2)
  40. Dehydroepiandrosterone,Androstenedione (1)
  41. Deoxyuridine monophosphate (dUMP) (1)
  42. Diacylglycerol (1)
  43. Dihydroorotate (2)
  44. DNA (3)
  45. DNA-damage response (4)
  46. DNA-RNA (108)
  47. dNTP (oxidized) (3)
  48. Dopamine (2)
  49. ECM-adhesion (6)
  50. EGF (13)
  51. EGF-VEGF (2)
  52. Eicosanoid epoxides (3)
  53. Endothelin; Non Selective (1)
  54. Ephrins (1)
  55. Farnesyl substrates (CaaX motif) (1)
  56. Fatty acid (Amides) (2)
  57. Fatty acid (Arachidonic acid) (10)
  58. Fatty acid (Linoleic acid) (1)
  59. Fatty acid (Stearic acid) (1)
  60. Fatty acids (3)
  61. FGF (9)
  62. FGF-VEGF (2)
  63. FLT3LG (4)
  64. Fructose 6-phosphate (2)
  65. G-Proteins (1)
  66. Gas6 (3)
  67. GDNF (2)
  68. Gluconeogenesis (1)
  69. Glucose (5)
  70. Glutathion (GSH) (1)
  71. Glycans (1)
  72. Glycine (3)
  73. Glycogen (1)
  74. Glycosides (3)
  75. Golgi apparatus (1)
  76. GTP (8)
  77. Hedgehog (2)
  78. Hemoglobin (2)
  79. HGF (8)
  80. HGF-VEGF (2)
  81. Histone (82)
  82. HMG-CoA (1)
  83. Hypoxanthine (2)
  84. Hypoxia-signaling cascade (6)
  85. IGF1 (3)
  86. Interleukin (5)
  87. Interleukin-8 (1)
  88. Isocitrate (4)
  89. IκB (7)
  90. JAK-STAT Pathway (15)
  91. Kinins (3)
  92. Kynurenine, L- (7)
  93. Lactate (1)
  94. LCCs, RyRs, and PLB (2)
  95. Lipid A precursor (3)
  96. LPC (1)
  97. LRP5 (1)
  98. Mannosidose (α form) (1)
  99. MAPK (41)
  100. MEK (11)
  101. Microtubules (5)
  102. Mono-amines (10)
  103. NADH (1)
  104. NADP+ (1)
  105. NADPH (2)
  106. NEDD8 (1)
  107. Neurotrophin (4)
  108. NF-κB Pathway (6)
  109. Nicotinamide D-ribonucleotide (3)
  110. Non Selective (45)
  111. Non Selective (ADF-cofilin) (4)
  112. Non Selective (Anions) (1)
  113. Non Selective (Arginine Sites Proteins) (8)
  114. Non Selective (Aspartate Peptide Bonds) (6)
  115. Non Selective (CHK2; p53) (8)
  116. Non Selective (COX substrates; Cannabinoids) (1)
  117. Non Selective (Cysteine Peptide Bonds) (3)
  118. Non Selective (Glucocorticoid) (1)
  119. Non Selective (glycosyl donors) (1)
  120. Non Selective (Histone; Survivin; Topo) (3)
  121. Non Selective (Histone; Survivin; Topo; TPX2) (5)
  122. Non Selective (Histone; Survivin; Topo; TPX2); JAK-STAT Pathway; Non Selective (Phosphorylation Substrates) (1)
  123. Non Selective (Ions; Na+Ca2+) (1)
  124. Non Selective (Ions; Na+H+) (1)
  125. Non Selective (LIM; p53; TPX2) (4)
  126. Non Selective (Lysine Sites Proteins) (1)
  127. Non Selective (Methionine Peptide Bonds) (1)
  128. Non Selective (Mitotic Spindle Checkpoint) (4)
  129. Non Selective (Noradrenaline; Dopamine) (1)
  130. Non Selective (Phosphorylation Substrates) (90)
  131. Non Selective (Phosphorylation Substrates); MAPK (1)
  132. Non Selective (Phosphorylation Substrates); MAPK; FGF-VEGF (1)
  133. Non Selective (Proline Peptide Bonds) (4)
  134. Non Selective (Ribosomal proteins) (5)
  135. Non Selective (Serine Peptide Bonds) (10)
  136. Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) (7)
  137. Non Selective (Serotonin; Noradrenaline) (10)
  138. Non Selective (Tripeptides) (1)
  139. Non Selective (Tyrosine Specific Phosphomonoesters) (8)
  140. Non Selective (Ubiquitin peptides) (22)
  141. NotchΔE-eGFP (1)
  142. p53 (11)
  143. Palmitoyl-CoA; L-serine (1)
  144. PDGF-FGF-VEGF (2)
  145. Phosphatidylcholine (1)
  146. Phosphatidylinositol (65)
  147. Phospholipids (3)
  148. Potassium (5)
  149. PP2A (1)
  150. Prostaglandins (1)
  151. Protein Disulfide Isomerase (PDI) (1)
  152. Protein Rad21 (1)
  153. Pyruvate (2)
  154. Quorum Sensing (1)
  155. RAS proteins (3)
  156. Retrograde trafficking (1)
  157. Ribosome rescue (2)
  158. S-nitrosoglutathione (1)
  159. S-palmitoylated proteins (1)
  160. SCF-FLT3-PDGF (2)
  161. SCF-PDGF-FGF (1)
  162. SCF-PDGF-VEGF (6)
  163. SCF-VEGF (2)
  164. Serotonin (7)
  165. Serpin (5)
  166. Smad (2)
  167. Sonic Hedgehog (2)
  168. Sphingosine (4)
  169. Stem cells (iPSC) (1)
  170. Steroid (Androgens) (1)
  171. Steroid (Lanosterol 14-α) (4)
  172. Steroids (1)
  173. Succinic acid (1)
  174. Superoxide (1)
  175. T-Cell activity (1)
  176. T-Cell signaling (1)
  177. TGF-β (3)
  178. Thrombin (1)
  179. Thymidylate pathway (1)
  180. TNF-α (6)
  181. Triglycerides (7)
  182. Unfolded Protein Response (EIF2 Selective) (3)
  183. Unfolded Protein Response (Non Selective) (6)
  184. Uric acid (2)
  185. VEGF (11)
  186. Water (3)
  187. Wnt proteins (6)
  188. Zinc (1)
  189. β-Lactams (1)
Filter by Action
  1. Activator (47)
  2. Agonist (242)
  3. Agonist (1)
  4. Agonist prodrug (1)
  5. Agonist; Building Block (3)
  6. Allosteric agonist (2)
  7. Allosteric agonist (1)
  8. Allosteric modulator (1)
  9. Antagonist (297)
  10. Antiprotozoal (1)
  11. Blocker (39)
  12. Building Block; (Unknown Pharmacology) (19)
  13. Chaperone (1)
  14. Chelator (1)
  15. Derivatisation Reagent (6)
  16. Downregulator (1)
  17. Fluorescent (2)
  18. HNO donor (2)
  19. Inactive (1)
  20. Inducer (4)
  21. Inhibitor
  22. Inverse agonist (6)
  23. Ionophore (2)
  24. Ligand (1)
  25. Metabolite (Unknown activity) (1)
  26. Modifier (1)
  27. Modulator (52)
  28. NAM (6)
  29. Negative modulator (1)
  30. Neurotoxin (1)
  31. Neurotrophic (1)
  32. Neutraligand (1)
  33. Opener (15)
  34. PAM (26)
  35. Partial agonist (2)
  36. Potentiator (1)
  37. Releasing agent (1)
  38. Stabilizer (3)
  39. Stimulator (6)
  40. Toxin (1)
  41. Unclassified (2)
  42. Upregulator (1)
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