Research Areas
In this section, by far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2089 | 7,8-Dihydroxyflavone | Tyrosine kinase receptor B (TrkB) agonist | €55.00 | |
| 1466 | A 769662 | AMPK activator | €85.00 | |
| 2389 | AICAR | Potent AMPK activator and inducer of differentiation of NSCs | €45.00 | |
| 2551 | Alda 1 | Small molecule activator of ALDH2 | €65.00 | |
| 2006 | Apoptosis Activator 2 | A cell-permeable apoptosis activator | €75.00 | |
| 3062 | AZD1656 | Glucokinase (GK) activator | €165.00 | |
| 2185 | BAM 7 | Selective small-molecule activator of proapoptotic BAX | €90.00 | |
| 2172 | BAY 58-2667 hydrochloride | Soluble, potent nitric oxide-independent guanylyl cyclase (sGC) activator | €125.00 | |
| 3431 | BTSA1 | Potent activator of proapoptotic BAX | €110.00 | |
| 2575 | C-DIM12 | Nurr1 activator that stimulates apoptosis in bladder cancer cells | €85.00 | |
| 2684 | CDN1163 | Allosteric Activator of SERCA2b | €90.00 | |
| 1835 | CK 1827452 | Cardiac specific myosin ATPase activator | €115.00 | |
| 2841 | COTI-2 | Reactivator of mutant p53 | €125.00 | |
| 2494 | D-Luciferin | Natural substrate of firefly luciferase. Compound for bioluminescence imaging (BLI) | €95.00 | |
| 2576 | Eact | Activator of TMEM16A (ANO1) without elevating cytoplasmic Ca2+ | €85.00 | |
| 2264 | Forskolin | Activator of adenylate cyclase. Naturally occurring labdane diterpene | €90.00 | |
| 3262 | HEI3090 | Positive modulator of the P2X7 receptor | €130.00 | |
| 2021 | HL 010183 | Metformin derivative; AMPK activator | €135.00 | |
| 2484 | K6PC-5 | SphK1 (or SK1) activator that increases sphingosine-1-phosphate production | €105.00 | |
| 2378 | Kartogenin | Promotor of chondrocyte differentiation from primary human MSCs | €75.00 | |
| 3482 | LDC7559 | PFKL activator | €155.00 | |
| 2260 | LDN 212320 | Activator of EAAT2 translation; neuroprotectant | €90.00 | |
| 2425 | MHY 1485 | mTOR activator with an inhibitory effect on autophagy | €70.00 | |
| 2149 | Mitapivat |
Activator of pyruvate kinase isoenzyme M2 (PKM2) |
€125.00 | |
| 3197 | Mitochonic acid 5 | Mitochondrial drug; Activator of MAPK-ERK-yap signalling | €90.00 | |
| 2436 | ML 297 | First potent and selective activator of the GIRK potassium channel | €95.00 | |
| 2872 | ML 335 | Selective activator of the TREK-1 and TREK-2 potassium channel | €115.00 | |
| 2980 | ML2-SA1 | Potent and selective activator of TRPML2 | €105.00 | |
| 3196 | ML277 | Potent and selective KCNQ1 channel activator | €80.00 | |
| 2641 | ML334 | Activator of NRF2 by inhibition of Keap1-NRF2 interactions | €130.00 | |