Research Areas

In this section, by  far, most Axon Ligands™ are categorized as research tools that find their application in cell signaling and oncology. Targeting a multitude of specific enzymes and receptors, they either stimulate or block particular cellular signaling pathways that are implicated in various kinds of cancer. Naturally, all products in this section can also be found by their specific biological targets as listed in the sections of enzymes, receptors, transcription factors, proteins and/or signaling pathways. Besides the comprehensive set of compounds that targe cell signaling and oncology, selections of Axon Ligands™ have also been made for other research area's such as cardiovascular diseases, angiogenisis, epigenetics, stem cell research, among many others.

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Axon ID Name Description From price
2089 7,8-Dihydroxyflavone Tyrosine kinase receptor B (TrkB) agonist €55.00
1466 A 769662 AMPK activator €85.00
2389 AICAR Potent AMPK activator and inducer of differentiation of NSCs €45.00
2551 Alda 1 Small molecule activator of ALDH2 €65.00
2006 Apoptosis Activator 2 A cell-permeable apoptosis activator €75.00
3062 AZD1656 Glucokinase (GK) activator €165.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
2172 BAY 58-2667 hydrochloride Soluble, potent nitric oxide-independent guanylyl cyclase (sGC) activator €125.00
3431 BTSA1 Potent activator of proapoptotic BAX €110.00
2575 C-DIM12 Nurr1 activator that stimulates apoptosis in bladder cancer cells €85.00
2684 CDN1163 Allosteric Activator of SERCA2b €90.00
1835 CK 1827452 Cardiac specific myosin ATPase activator €115.00
2841 COTI-2 Reactivator of mutant p53 €125.00
2494 D-Luciferin Natural substrate of firefly luciferase. Compound for bioluminescence imaging (BLI) €95.00
2576 Eact Activator of TMEM16A (ANO1) without elevating cytoplasmic Ca2+ €85.00
2264 Forskolin Activator of adenylate cyclase. Naturally occurring labdane diterpene €90.00
3262 HEI3090 Positive modulator of the P2X7 receptor €130.00
2021 HL 010183 Metformin derivative; AMPK activator €135.00
2484 K6PC-5 SphK1 (or SK1) activator that increases sphingosine-1-phosphate production €105.00
2378 Kartogenin Promotor of chondrocyte differentiation from primary human MSCs €75.00
3482 LDC7559 PFKL activator €155.00
2260 LDN 212320 Activator of EAAT2 translation; neuroprotectant €90.00
2425 MHY 1485 mTOR activator with an inhibitory effect on autophagy €70.00
2149 Mitapivat

Activator of pyruvate kinase isoenzyme M2 (PKM2)

€125.00
3197 Mitochonic acid 5 Mitochondrial drug; Activator of MAPK-ERK-yap signalling €90.00
2436 ML 297 First potent and selective activator of the GIRK potassium channel €95.00
2872 ML 335 Selective activator of the TREK-1 and TREK-2 potassium channel €115.00
2980 ML2-SA1 Potent and selective activator of TRPML2 €105.00
3196 ML277 Potent and selective KCNQ1 channel activator €80.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €130.00

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