Stem Cell

Axon Ligands™ for Stem Cell Research

The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:

Stem cell → Stem cell + Progenitor cell → Differentiated cell 

Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs).  They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.

Among the types of differentiation are:

  • Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
  • Transdifferentiation: direct conversion of one cell type to another different cell type;
  • Dedifferentiation: unipotent stem cell becoming a multipotent one;
  • Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]

Stem cell products Library

For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5053 - Stem cell Library.xls                   


The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:

Enzymes

 

 

AMPK

CDC42

CHK

CK

DNA methyltransferase

GSK-3

HHAT

HMTase

JAK

MEK

MPS1 Kinase

mTOR

PI3K

Porcupine

Rac

ROCK

TNKS

γ-Secretase

Receptors

 

 

BMP-ALK

FGFR

Smoothened (SMO)

TGF-βR

 

 

Ion Channels

 

 

Ca Channel

 

 

Signaling pathways

 

 

Hedgehog

TGF-β/SMAD

Wnt/β-Catenin

Transcription factors

 

 

AHR

STAT

 

Proteins

 

 

Aggrecan

β-Catenin

 

Related product categories: Stem cell differentiators, Stem cell inhibitor sets


[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.

Items 121 to 150 of 195 total

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Axon ID Name Description From price
1408 PD 0325901 MEK1 and MEK2 inhibitor €50.00
2098 PD 161570 Selective FGFR1 inhibitor €75.00
1673 PD 173074 FGFR1 and FGFR3 inhibitor €75.00
1368 PD 184352 MEK 1 inhibitor €80.00
1223 PD 98059 MEK inhibitor €80.00
2501 Pexidartinib Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3 €60.00
1379 PF 477736 CHK1 inhibitor €70.00
1792 PF 4800567 Inhibitor of Casein kinase 1 (CK1-ε) €95.00
2027 PF 5274857 hydrochloride Smoothened (SMO) antagonist €95.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
3051 Pifithrin-β Inhibitor of p53 protein; Condensation product of Pifithrin-α €95.00
2091 PluriSIn #1 Inhibitor of stearoyl-coA desaturase (SCD1) €75.00
3749 PRI-724 Specific inhibitor of Wnt/β-catenin signaling pathway  Recently added Inquire
1659 PS 48 Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1) €80.00
2420 PTC 209 Inhibitor of the canonical self-renewal regulator BMI-1 €125.00
1690 Purmorphamine Hedgehog signaling pathway activator €110.00
3480 PY-60 Specific YAP activator targeting ANXA2 €150.00
2999 RCGD 423 gp130 signalling modulator €95.00
1629 Reversine MPS1 kinase inhibitor €85.00
1691 RG 108 DNA methyltransferase inhibitor €80.00
2229 RKI 1447 Potent inhibitor of the Rho-associated ROCK kinases €105.00
2521 RO 4929097 Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells €135.00
2035 RU-SKI 43 hydrochloride Hedgehog acyltransferase (HHAT) inhibitor blocks Shh signaling €105.00
2673 RUSKI-201 dihydrochloride Sonic HHAT inhibitor lacking off-target cytotoxicity €135.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €90.00
1363 SB 203580 MAPK inhibitor (p38 specific) €95.00
1465 SB 203580 hydrochloride MAPK inhibitor (p38 specific) €70.00
1303 SB 216763 GSK-3 inhibitor €85.00
1661 SB 431542 TGF-βR1 inhibitor; ALK inhibitor €70.00
2197 SB 505124 Selective inhibitor of TGF-β type I receptors ALK4 and ALK5 €95.00

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