Stem Cell

Axon Ligands™ for Stem Cell Research

The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:

Stem cell → Stem cell + Progenitor cell → Differentiated cell 

Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs).  They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.

Among the types of differentiation are:

  • Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
  • Transdifferentiation: direct conversion of one cell type to another different cell type;
  • Dedifferentiation: unipotent stem cell becoming a multipotent one;
  • Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]

Stem cell products Library

For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5053 - Stem cell Library.xls                   


The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:

Enzymes

 

 

AMPK

CDC42

CHK

CK

DNA methyltransferase

GSK-3

HHAT

HMTase

JAK

MEK

MPS1 Kinase

mTOR

PI3K

Porcupine

Rac

ROCK

TNKS

γ-Secretase

Receptors

 

 

BMP-ALK

FGFR

Smoothened (SMO)

TGF-βR

 

 

Ion Channels

 

 

Ca Channel

 

 

Signaling pathways

 

 

Hedgehog

TGF-β/SMAD

Wnt/β-Catenin

Transcription factors

 

 

AHR

STAT

 

Proteins

 

 

Aggrecan

β-Catenin

 

Related product categories: Stem cell differentiators, Stem cell inhibitor sets


[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.

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Axon ID Name Description From price
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €95.00
2656 CRT0066854 Selective ATP-competitive inhibitor of the atypical PKC isoenzymes €135.00
1965 CX 4945 hydrochloride Inhibitor of Casein kinase 2 (CK2) €90.00
2895 D3-βArr Positive allosteric modulator (PAM) of TSH receptor €105.00
1484 DAPT γ-Secretase inhibitor €90.00
2476 DEAB Potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes €50.00
1590 Decitabine DNA methyltransferase inhibitor €85.00
3018 DJ001 Selective, non-competitive, allosteric inhibitor of PTPσ €125.00
1708 Dorsomorphin Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 €65.00
2150 Dorsomorphin dihydrochloride Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 €65.00
2701 EED226 Potent, selective and orally bioavailable PRC2 inhibitor €105.00
2351 EHop 016 Rac GTPase inhibitor specific for Rac1 and Rac3 €85.00
1872 Eltrombopag Thrombopoietin receptor (TpoR or c-MPL) agonist €95.00
2320 FH 1 Promotes the maturation and differentiation of iPSCs to hepatocytes €50.00
2277 FLI 06 Notch signaling inhibitor that acts early in the secretory pathway €95.00

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