Stem Cell

Axon Ligands™ for Stem Cell Research

The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:

Stem cell → Stem cell + Progenitor cell → Differentiated cell 

Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs).  They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.

Among the types of differentiation are:

  • Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
  • Transdifferentiation: direct conversion of one cell type to another different cell type;
  • Dedifferentiation: unipotent stem cell becoming a multipotent one;
  • Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]

Stem cell products Library

For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5053 - Stem cell Library.xls                   


The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:

Enzymes

 

 

AMPK

CDC42

CHK

CK

DNA methyltransferase

GSK-3

HHAT

HMTase

JAK

MEK

MPS1 Kinase

mTOR

PI3K

Porcupine

Rac

ROCK

TNKS

γ-Secretase

Receptors

 

 

BMP-ALK

FGFR

Smoothened (SMO)

TGF-βR

 

 

Ion Channels

 

 

Ca Channel

 

 

Signaling pathways

 

 

Hedgehog

TGF-β/SMAD

Wnt/β-Catenin

Transcription factors

 

 

AHR

STAT

 

Proteins

 

 

Aggrecan

β-Catenin

 

Related product categories: Stem cell differentiators, Stem cell inhibitor sets


[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.

Items 91 to 120 of 210 total

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Axon ID Name Description From price
2323 ITD 1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis €105.00
2212 IWP L6 Highly potent porcupine (Porcn) inhibitor €130.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €90.00
3721 JAB-3068 SHP2 inhibitor €240.00
2654 JK184 Hedgehog (Hh) signaling pathway antagonist with antiproliferative activity €80.00
1922 JW 55 Inhibitor of tankyrase (TNKS 1 and 2) €95.00
2189 K 02288 Inhibitor of BMP signaling. Inhibits ALK1, 2, and 6 €90.00
2378 Kartogenin Promotor of chondrocyte differentiation from primary human MSCs €75.00
2901 KHS101 hydrochloride Selective, brain-penetrable inducer of neuronal differentiation and TACC3 inhibitor €95.00
1472 KU-0063794 mTOR inhibitor €60.00
2036 KY 02111 Canonical Wnt signaling pathway inhibitor €80.00
2668 KYA1797K Promotor of β-catenin and Ras degradation that effectively suppresses the growth of CRCs €95.00
1509 LDN 193189 hydrochloride Highly potent small molecule inhibitor of BMP type I receptors ALK2, ALK3, and ALK6 €65.00
3552 LDN 212854 Potent ALK2-biased BMP type I receptor kinase inhibitor €110.00
2201 LDN 212854 trihydrochloride Potent ALK2-biased BMP type I receptor kinase inhibitor €110.00
2297 LH 846 Inhibitor of Casein kinase 1 (CK1δ) €95.00
2223 Lomeguatrib Potent, orally active inhibitor of MGMT €135.00
2869 LX2343 BACE 1 inhibitor €125.00
1491 LY 2157299 TGF-βR2 inhibitor €60.00
2553 LY 2801653 Orally bioavailable multi-kinase inhibitor with potent activity against c-MET €120.00
1366 LY 294002 PI3K inhibitor €70.00
2196 LY 2940680 Small-molecule antagonist of the Smoothened (SMO) receptor €120.00
4145 LY2606368 mesylate Potent and selective ATP competitive inhibitor of the CHK protein kinase  Recently added Inquire
3880 MCI-INI-3 Potent and selective ALDH1A3 inhibitor  Recently added €130.00
3628 MHY-1685 mTOR inhibitor; Senescence inhibitor €50.00
1494 MK 1775 Wee1 kinase inhibitor €80.00
2871 ML 239 Selective inhibitor of breast cancer stem cells €95.00
2358 Mps1-IN-2 Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 €95.00
1938 MRT 10 Smoothened (SMO) receptor antagonist €125.00
3342 MSAB Potent and selective inhibitor of Wnt/β-catenin signaling pathway €80.00

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