Stem Cell
The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:
Stem cell → Stem cell + Progenitor cell → Differentiated cell
Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs). They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.
Among the types of differentiation are:
- Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
- Transdifferentiation: direct conversion of one cell type to another different cell type;
- Dedifferentiation: unipotent stem cell becoming a multipotent one;
- Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]
Stem cell products Library
For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
 Axon 5053 - Stem cell Library.xls |
The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:
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Related product categories: Stem cell differentiators, Stem cell inhibitor sets
[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2189 | K 02288 | Inhibitor of BMP signaling. Inhibits ALK1, 2, and 6 | €90.00 | |
| 2378 | Kartogenin | Promotor of chondrocyte differentiation from primary human MSCs | €75.00 | |
| 2901 | KHS101 hydrochloride | Selective, brain-penetrable inducer of neuronal differentiation and TACC3 inhibitor | €95.00 | |
| 1472 | KU-0063794 | mTOR inhibitor | €60.00 | |
| 2036 | KY 02111 | Canonical Wnt signaling pathway inhibitor | €80.00 | |
| 2668 | KYA1797K | Promotor of β-catenin and Ras degradation that effectively suppresses the growth of CRCs | €95.00 | |
| 1509 | LDN 193189 hydrochloride | Highly potent small molecule inhibitor of BMP type I receptors ALK2, ALK3, and ALK6 | €65.00 | |
| 3552 | LDN 212854 | Potent ALK2-biased BMP type I receptor kinase inhibitor | €110.00 | |
| 2201 | LDN 212854 trihydrochloride | Potent ALK2-biased BMP type I receptor kinase inhibitor | €110.00 | |
| 2297 | LH 846 | Inhibitor of Casein kinase 1 (CK1δ) | €95.00 | |
| 2223 | Lomeguatrib | Potent, orally active inhibitor of MGMT | €135.00 | |
| 2869 | LX2343 | BACE 1 inhibitor | €125.00 | |
| 1491 | LY 2157299 | TGF-βR2 inhibitor | €60.00 | |
| 2553 | LY 2801653 | Orally bioavailable multi-kinase inhibitor with potent activity against c-MET | €120.00 | |
| 1366 | LY 294002 | PI3K inhibitor | €70.00 | |
| 2196 | LY 2940680 | Small-molecule antagonist of the Smoothened (SMO) receptor | €120.00 | |
| 3628 | MHY-1685 | mTOR inhibitor; Senescence inhibitor | €50.00 | |
| 1494 | MK 1775 | Wee1 kinase inhibitor | €80.00 | |
| 2871 | ML 239 | Selective inhibitor of breast cancer stem cells | €95.00 | |
| 2358 | Mps1-IN-2 | Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 | €95.00 | |
| 1938 | MRT 10 | Smoothened (SMO) receptor antagonist | €125.00 | |
| 3342 | MSAB | Potent and selective inhibitor of Wnt/β-catenin signaling pathway | €80.00 | |
| 5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
| 5010 | Naive Stem Cell NHSM inhibitor Set | Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs | €230.00 | |
| 2517 | Napabucasin | Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 | €105.00 | |
| 2322 | Neuropathiazol | Selective inducer of neural differentiation of adult hippocampal neural progenitor cells (NPCs). | €135.00 | |
| 2702 | NQ301 | Selective allosteric inhibitor of CD45 | €90.00 | |
| 2695 | NSC 23005 sodium | Novel small molecule inhibitor of INK4C (p18(INK4C) or p18) | €90.00 | |
| 1578 | NSC 23766 | Rac1 inhibitor | €110.00 | |
| 1619 | NVP-LDE225 | Smoothened (SMO) antagonist | €85.00 | |