Stem Cell
The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:
Stem cell → Stem cell + Progenitor cell → Differentiated cell
Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs). They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.
Among the types of differentiation are:
- Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
- Transdifferentiation: direct conversion of one cell type to another different cell type;
- Dedifferentiation: unipotent stem cell becoming a multipotent one;
- Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]
Stem cell products Library
For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
 Axon 5053 - Stem cell Library.xls |
The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:
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Signaling pathways |
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Proteins |
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Related product categories: Stem cell differentiators, Stem cell inhibitor sets
[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3715 | E-7386 | CBP/beta-catenin modulator | Inquire | |
| 2701 | EED226 | Potent, selective and orally bioavailable PRC2 inhibitor | €90.00 | |
| 2351 | EHop 016 | Rac GTPase inhibitor specific for Rac1 and Rac3 | €85.00 | |
| 1872 | Eltrombopag | Thrombopoietin receptor (TpoR or c-MPL) agonist | €95.00 | |
| 2320 | FH 1 | Promotes the maturation and differentiation of iPSCs to hepatocytes | €50.00 | |
| 2277 | FLI 06 | Notch signaling inhibitor that acts early in the secretory pathway | €95.00 | |
| 2959 | FM19G11 | Potent HIFα inhibitor | €95.00 | |
| 2264 | Forskolin | Activator of adenylate cyclase. Naturally occurring labdane diterpene | €90.00 | |
| 2355 | FPH 2 | Proliferation inducer of mature human primary hepatocytes | €110.00 | |
| 1500 | GDC 0449 | Hedgehog (Hh) pathway inhibitor | €80.00 | |
| 1377 | GDC 0941 bismesylate | PI3K inhibitor | €85.00 | |
| 3767 | GDC-1971 | Orally available, potent, and selective inhibitor of the protein tyrosine phosphatase SHP2 | Inquire | |
| 2466 | Gö 6983 | Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ | €90.00 | |
| 1167 | GSK 269962A | ROCK1 and ROCK2 inhibitor | €65.00 | |
| 3757 | GSK3685032 hydrochloride | Potent first-in-class DNMT1-selective inhibitor | Inquire | |
| 1832 | GW 788388 | TGF-βR 1 inhibitor | €50.00 | |
| 2021 | HL 010183 | Metformin derivative; AMPK activator | €135.00 | |
| 1440 | HU 308 | CB2 agonist | €140.00 | |
| 3811 | Icaritin | Natural flavonoid with potent cytotoxic and osteogenic activity | Recently added | €95.00 |
| 1766 | ICG 001 | Specific inhibitor of Wnt/β-catenin signaling pathway | €115.00 | |
| 2135 | iCRT14 | Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor | €135.00 | |
| 2133 | iCRT5 | β-Catenin-responsive transcription (CRT) inhibitor | €80.00 | |
| 2511 | IM 12 | GSK-3β inhibitor attenuating neuronal differentiation of human NPCs | €95.00 | |
| 2236 | IN 1130 | TGF-βR 1 inhibitor | €95.00 | |
| 2323 | ITD 1 | Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis | €105.00 | |
| 2212 | IWP L6 | Highly potent porcupine (Porcn) inhibitor | €125.00 | |
| 2510 | IWR-1-endo | Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 | €85.00 | |
| 3721 | JAB-3068 | SHP2 inhibitor | Inquire | |
| 2654 | JK184 | Hedgehog (Hh) signaling pathway antagonist with antiproliferative activity | €80.00 | |
| 1922 | JW 55 | Inhibitor of tankyrase (TNKS 1 and 2) | €95.00 | |