Stem Cell

Axon Ligands™ for Stem Cell Research

The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:

Stem cell → Stem cell + Progenitor cell → Differentiated cell 

Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs).  They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.

Among the types of differentiation are:

  • Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
  • Transdifferentiation: direct conversion of one cell type to another different cell type;
  • Dedifferentiation: unipotent stem cell becoming a multipotent one;
  • Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]

Stem cell products Library

For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5053 - Stem cell Library.xls                   


The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:

Enzymes

 

 

AMPK

CDC42

CHK

CK

DNA methyltransferase

GSK-3

HHAT

HMTase

JAK

MEK

MPS1 Kinase

mTOR

PI3K

Porcupine

Rac

ROCK

TNKS

γ-Secretase

Receptors

 

 

BMP-ALK

FGFR

Smoothened (SMO)

TGF-βR

 

 

Ion Channels

 

 

Ca Channel

 

 

Signaling pathways

 

 

Hedgehog

TGF-β/SMAD

Wnt/β-Catenin

Transcription factors

 

 

AHR

STAT

 

Proteins

 

 

Aggrecan

β-Catenin

 

Related product categories: Stem cell differentiators, Stem cell inhibitor sets


[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.

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Axon ID Name Description From price
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
5053 Axon Ligands™ Stem cell compound library Axon Ligands™ Stem cell compound library Inquire
2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β €110.00
2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
1693 BIO GSK-3 inhibitor €95.00
1126 CHIR 98014 GSK-3 inhibitor €99.00
1386 CHIR 99021 GSK-3 inhibitor €60.00
2435 CHIR 99021 dihydrochloride GSK-3 inhibitor €60.00
2202 CK2 inhibitor 10 Potent and ATP-competitive inhibitor of CK2 €105.00
3279 CKI-7 dihydrochloride Selective inhibitor of Casein kinase 1 €120.00
2656 CRT0066854 Selective ATP-competitive inhibitor of the atypical PKC isoenzymes €135.00
1965 CX 4945 hydrochloride Inhibitor of Casein kinase 2 (CK2) €90.00
2466 Gö 6983 Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ €90.00
1167 GSK 269962A ROCK1 and ROCK2 inhibitor €65.00
2511 IM 12 GSK-3β inhibitor attenuating neuronal differentiation of human NPCs €95.00
2297 LH 846 Inhibitor of Casein kinase 1 (CK1δ) €95.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €230.00
1792 PF 4800567 Inhibitor of Casein kinase 1 (CK1-ε) €95.00
2229 RKI 1447 Potent inhibitor of the Rho-associated ROCK kinases €105.00
1303 SB 216763 GSK-3 inhibitor €85.00
2547 SR 3029 A potent, highly specific CK1δ/CK1ε inhibitor €135.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD 0325901, and CHIR 99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €170.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €200.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €100.00
5006 Stem Cell CSD inhibitor Set Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €140.00
2010 TDZD 8 Selective and non-ATP-competitive inhibitor of GSK-3β €90.00

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