Stem Cell

Axon Ligands™ for Stem Cell Research

The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:

Stem cell → Stem cell + Progenitor cell → Differentiated cell 

Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs).  They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.

Among the types of differentiation are:

  • Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
  • Transdifferentiation: direct conversion of one cell type to another different cell type;
  • Dedifferentiation: unipotent stem cell becoming a multipotent one;
  • Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]

Stem cell products Library

For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5053 - Stem cell Library.xls                   


The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:

Enzymes

 

 

AMPK

CDC42

CHK

CK

DNA methyltransferase

GSK-3

HHAT

HMTase

JAK

MEK

MPS1 Kinase

mTOR

PI3K

Porcupine

Rac

ROCK

TNKS

γ-Secretase

Receptors

 

 

BMP-ALK

FGFR

Smoothened (SMO)

TGF-βR

 

 

Ion Channels

 

 

Ca Channel

 

 

Signaling pathways

 

 

Hedgehog

TGF-β/SMAD

Wnt/β-Catenin

Transcription factors

 

 

AHR

STAT

 

Proteins

 

 

Aggrecan

β-Catenin

 

Related product categories: Stem cell differentiators, Stem cell inhibitor sets


[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
[3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.

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Axon ID Name Description From price
1488 γ-Secretase Inhibitor DBZ γ-Secretase inhibitor (GSI) €80.00
1487 γ-Secretase Inhibitor BZ γ-Secretase inhibitor (GSI) €90.00
2445 ZLN 024 Allosteric activator of AMP-activated protein kinase (AMPK) €90.00
1254 Zebularine DNA methyltransferase inhibitor €95.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00
1683 Y 27632 dihydrochloride ROCK1 and ROCK2 inhibitor €65.00
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2287 Wnt-C59 Highly potent porcupine (Porcn) inhibitor €75.00
2120 Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00
2381 WH-4-023 Orally active src-family selective lck inhibitor €90.00
2188 WAY 262611 dihydrochloride Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist €125.00
2520 U 0126 Non-competitive inhibitor of MEK1/2 and protects brain in stroke models €90.00
1562 TWS 119 GSK-3β inhibitor €70.00
1854 TTP 22 Inhibitor of Casein kinase 2 (CK2) €105.00
3276 TRULI LATS1/2 inhibitor €120.00
2723 TPI-1 Selective SHP1 inhibitor €95.00
1535 Thiazovivin ROCK inhibitor and iPSC stimulator; Stem cell related €90.00
2010 TDZD 8 Selective and non-ATP-competitive inhibitor of GSK-3β €90.00
2755 TC Mps1 12 Potent and selective inhibitor of MPS1 kinase €115.00
1136 SU 6656 SRC kinase inhibitor €120.00
1667 SU 5402 Fibroblast growth factor receptor (FGFR) inhibitor €60.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00
5008 Stem Cell RG-BIX inhibitor Set Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively €60.00
5005 Stem Cell LSC inhibitor Set Set of LDN 193189 HCl, SB 431542 and CHIR 99021, inhibitors of BMP, TGF-β, and GSK-3 resp. €130.00
5004 Stem Cell LSB inhibitor Set Set of BMP inhibitor LDN 193189 (Axon 1509) and TGF-β inhibitor SB 431542 (Axon 1661) €90.00
5006 Stem Cell CSD inhibitor Set Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €140.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €100.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €200.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD 0325901, and CHIR 99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €170.00

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