Immunology

Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of bacteria and viral infections, for example. The immune system also performs surveillance of tumor cells, and immune suppression has been reported to increase the risk of certain types of cancer. Disorders of the immune system can result in a multitude of diseases. When the immune system is less active than normal, immunodeficiency occurs resulting in recurring and life-threatening infections. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms.
The immune system is composed of two major parts: the innate immune system and the adaptive immune system. The innate, or non-specific immune system comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner, and is present in all living organisms and comes into play immediately or within hours of an antigen's appearance in the body. Innate responses use phagocytic cells (neutrophils, monocytes and macrophages) and natural killer cells that use a primitive non-specific recognition system that allows them to bind, internalize and kill a variety of micro-organisms and exogenous molecules. The molecular components of innate reponse include complement, acute-phase proteins and cytokines such as interferons. The adaptive immune system however, effectuates an antigen-specific immune response and confers long-lasting or protective immunity to the host and is only found in vertebrates. This kind of immune response involves antigen-presenting cells (APCs), B and T cells. APCs are a heterogenous population of leukocytes with a immunostimulatory function[1].


[1] C.A. Janeway Jr, P. Travers, M. Walport et al. Immunobiology: The Immune System in Health and Disease. 5th edition.New York. Garland Science, 2001.

 

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Axon ID Name Description From price
3465 Amenamevir Potent helicase-primase inhibitor €130.00
3220 ARN24139 Orally active topoisomerase II poison €130.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €130.00
2042 Azithromycin Macrolide antibiotic; Binds the 50S ribosomal subunit €50.00
2266 BAY 57-1293 Potent helicase-primase inhibitor, effective against herpes simplex virus (HSV) infections €80.00
2301 BIBR 1532 Potent and selective telomerase inhibitor inducing senescence in human cancer cells. €70.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
3445 Clarithromycin Macrolide antibiotic; Binds the 50S ribosomal subunit €50.00
2063 Clindamycin Inhibitor of peptidyl transferase; Antibiotic €75.00
2391 CS1 TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects €135.00
3155 CU-115 Selective TLR8 inhibitor €120.00
2455 CU-T12-9 Selective TLR1/TLR2 agonist that facilitates the TLR1/2 complex formation €120.00
2173 CX 5461 Inhibitor of RNA Polymerase I (RNAP1) €120.00
1534 Dapivirine NNRT inhibitor €80.00
1815 Delavirdine NNRT inhibitor (HIV-1) €90.00
3125 Efavirenz Highly potent, orally bioavailable NNRT inhibitor (HIV-1) €60.00
3305 Emtricitabine Potent and orally bioavailable NRT inhibitor (HIV-1) €60.00
2318 FC 99 hydrochloride Inhibitor of TLR3 expression and inflammatory responses. €95.00
2157 FQI 1 Inhibitor of α-globin transcription factor CP2 (LSF) €95.00
3171 Gatifloxacin hydrochloride Inhibitor of bacterial DNA gyrase and topoisomerase IV €50.00
3107 Imiquimod TLR7/TLR8 agonist €60.00
3191 Islatravir Potent and long-acting NRT inhibitor (HIV-1) €220.00
2597 KPT 335 XPO1 inhibitor; selective inhibitor of nuclear export (SINE) €95.00
3683 L6H21 Specific MD-2 inhibitor €120.00
2242 Levofloxacin Q-acid Inhibitor of bacterial DNA gyrase and topoisomerase IV €55.00
3728 LHC-165 Agonist (activator) of Toll-like Receptor 7  Recently added Inquire
2048 Linezolid Protein synthesis inhibitor; antibiotic €80.00
3334 Loviride Potent and highly selective NNRT inhibitor (HIV-1) €140.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €130.00
2671 ML385 Inhibitor of NRF2 €120.00

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