Immunology
Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of bacteria and viral infections, for example. The immune system also performs surveillance of tumor cells, and immune suppression has been reported to increase the risk of certain types of cancer. Disorders of the immune system can result in a multitude of diseases. When the immune system is less active than normal, immunodeficiency occurs resulting in recurring and life-threatening infections. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms.
The immune system is composed of two major parts: the innate immune system and the adaptive immune system. The innate, or non-specific immune system comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner, and is present in all living organisms and comes into play immediately or within hours of an antigen's appearance in the body. Innate responses use phagocytic cells (neutrophils, monocytes and macrophages) and natural killer cells that use a primitive non-specific recognition system that allows them to bind, internalize and kill a variety of micro-organisms and exogenous molecules. The molecular components of innate reponse include complement, acute-phase proteins and cytokines such as interferons. The adaptive immune system however, effectuates an antigen-specific immune response and confers long-lasting or protective immunity to the host and is only found in vertebrates. This kind of immune response involves antigen-presenting cells (APCs), B and T cells. APCs are a heterogenous population of leukocytes with a immunostimulatory function[1].
[1] C.A. Janeway Jr, P. Travers, M. Walport et al. Immunobiology: The Immune System in Health and Disease. 5th edition.New York. Garland Science, 2001.
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Axon ID | Name | Description | From price | |
---|---|---|---|---|
3382 | Zidovudine | NRT inhibitor | €50.00 | |
3585 | Vesatolimod | Potent, selective and orally available TLR7 agonist | €80.00 | |
2100 | Trovafloxacin mesylate | Inhibitor of bacterial DNA gyrase and Topo IV | €110.00 | |
3302 | Tenofovir alafenamide | Prodrug of Tenofovir; HIV-1 reverse transcriptase inhibitor | €70.00 | |
3157 | Tenofovir | Selective inhibitor of HIV-1 reverse transcriptase | €60.00 | |
3491 | Stavudine | NRT inhibitor | €60.00 | |
2314 | Stattic | Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation | €50.00 | |
2731 | STAT5 Inhibitor 1 [285986-31-4] | Nonpeptidic small-molecule inhibitor of STAT5 activation | €90.00 | |
2200 | SRPIN 340 | Selective ATP-competitive inhibitor of SRPK kinase activity | €95.00 | |
2606 | Solithromycin | Fluoroketolide antibiotic | €135.00 | |
2313 | S3I 201 | Potent, cellular STAT3 inhibitor | €90.00 | |
3685 | Rilpivirine | Highly active and orally bioavailable NNRT inhibitor (HIV-1) | €95.00 | |
1704 | REP 8839 | MetRS inhibitor | €130.00 | |
1705 | REP 3123 dihydrochloride | MetRS inhibitor | €130.00 | |
2266 | Pritelivir | Potent helicase-primase inhibitor, effective against herpes simplex virus (HSV) infections | €50.00 | |
1762 | PNU 100480 | Ribosomal peptidyl transferase center (PTC) inhibitor | €60.00 | |
2497 | Omaveloxolone | Triterpenoid activator of NRF2 and inhibitor of NF-κB | €90.00 | |
3124 | Nevirapine | Potent and selective NNRT inhibitor (HIV-1) | €50.00 | |
2517 | Napabucasin | Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 | €105.00 | |
3229 | MYCi975 | MYC inhibitor | €120.00 | |
2783 | Motolimod | Highly potent and selective TLR8 agonist | €145.00 | |
2671 | ML385 | Inhibitor of NRF2 | €120.00 | |
2641 | ML334 | Activator of NRF2 by inhibition of Keap1-NRF2 interactions | €130.00 | |
3334 | Loviride | Potent and highly selective NNRT inhibitor (HIV-1) | €140.00 | |
2048 | Linezolid | Protein synthesis inhibitor; antibiotic | €80.00 | |
3728 | LHC-165 | Agonist (activator) of Toll-like Receptor 7 | Inquire | |
2242 | Levofloxacin Q-acid | Inhibitor of bacterial DNA gyrase and topoisomerase IV | €55.00 | |
3683 | L6H21 | Specific MD-2 inhibitor | €120.00 | |
2597 | KPT 335 | XPO1 inhibitor; selective inhibitor of nuclear export (SINE) | €95.00 | |
3191 | Islatravir | Potent and long-acting NRT inhibitor (HIV-1) | €140.00 |