Immunology

Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of bacteria and viral infections, for example. The immune system also performs surveillance of tumor cells, and immune suppression has been reported to increase the risk of certain types of cancer. Disorders of the immune system can result in a multitude of diseases. When the immune system is less active than normal, immunodeficiency occurs resulting in recurring and life-threatening infections. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms.
The immune system is composed of two major parts: the innate immune system and the adaptive immune system. The innate, or non-specific immune system comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner, and is present in all living organisms and comes into play immediately or within hours of an antigen's appearance in the body. Innate responses use phagocytic cells (neutrophils, monocytes and macrophages) and natural killer cells that use a primitive non-specific recognition system that allows them to bind, internalize and kill a variety of micro-organisms and exogenous molecules. The molecular components of innate reponse include complement, acute-phase proteins and cytokines such as interferons. The adaptive immune system however, effectuates an antigen-specific immune response and confers long-lasting or protective immunity to the host and is only found in vertebrates. This kind of immune response involves antigen-presenting cells (APCs), B and T cells. APCs are a heterogenous population of leukocytes with a immunostimulatory function[1].


[1] C.A. Janeway Jr, P. Travers, M. Walport et al. Immunobiology: The Immune System in Health and Disease. 5th edition.New York. Garland Science, 2001.

 

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Axon ID Name Description From price
3382 Zidovudine NRT inhibitor €50.00
3585 Vesatolimod Potent, selective and orally available TLR7 agonist €80.00
2100 Trovafloxacin mesylate Inhibitor of bacterial DNA gyrase and Topo IV €110.00
3302 Tenofovir alafenamide Prodrug of Tenofovir; HIV-1 reverse transcriptase inhibitor €70.00
3157 Tenofovir Selective inhibitor of HIV-1 reverse transcriptase €60.00
3491 Stavudine NRT inhibitor €60.00
2314 Stattic Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation €50.00
2731 STAT5 Inhibitor 1 [285986-31-4] Nonpeptidic small-molecule inhibitor of STAT5 activation €90.00
2200 SRPIN 340 Selective ATP-competitive inhibitor of SRPK kinase activity €95.00
2606 Solithromycin Fluoroketolide antibiotic €135.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €90.00
3685 Rilpivirine Highly active and orally bioavailable NNRT inhibitor (HIV-1) €95.00
1704 REP 8839 MetRS inhibitor €125.00
1705 REP 3123 dihydrochloride MetRS inhibitor €125.00
1762 PNU 100480 Ribosomal peptidyl transferase center (PTC) inhibitor €60.00
2497 Omaveloxolone Triterpenoid activator of NRF2 and inhibitor of NF-κB €90.00
3124 Nevirapine Potent and selective NNRT inhibitor (HIV-1) €50.00
2517 Napabucasin Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 €105.00
3229 MYCi975 MYC inhibitor €110.00
2783 Motolimod Highly potent and selective TLR8 agonist €145.00
2671 ML385 Inhibitor of NRF2 €120.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €130.00
3334 Loviride Potent and highly selective NNRT inhibitor (HIV-1) €140.00
2048 Linezolid Protein synthesis inhibitor; antibiotic €80.00
3728 LHC-165 Agonist (activator) of Toll-like Receptor 7 Inquire
2242 Levofloxacin Q-acid Inhibitor of bacterial DNA gyrase and topoisomerase IV €55.00
3683 L6H21 Specific MD-2 inhibitor €120.00
2597 KPT 335 XPO1 inhibitor; selective inhibitor of nuclear export (SINE) €95.00
3191 Islatravir Potent and long-acting NRT inhibitor (HIV-1) €220.00
3107 Imiquimod TLR7/TLR8 agonist €60.00

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