Immunology

Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of bacteria and viral infections, for example. The immune system also performs surveillance of tumor cells, and immune suppression has been reported to increase the risk of certain types of cancer. Disorders of the immune system can result in a multitude of diseases. When the immune system is less active than normal, immunodeficiency occurs resulting in recurring and life-threatening infections. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms.
The immune system is composed of two major parts: the innate immune system and the adaptive immune system. The innate, or non-specific immune system comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner, and is present in all living organisms and comes into play immediately or within hours of an antigen's appearance in the body. Innate responses use phagocytic cells (neutrophils, monocytes and macrophages) and natural killer cells that use a primitive non-specific recognition system that allows them to bind, internalize and kill a variety of micro-organisms and exogenous molecules. The molecular components of innate reponse include complement, acute-phase proteins and cytokines such as interferons. The adaptive immune system however, effectuates an antigen-specific immune response and confers long-lasting or protective immunity to the host and is only found in vertebrates. This kind of immune response involves antigen-presenting cells (APCs), B and T cells. APCs are a heterogenous population of leukocytes with a immunostimulatory function[1].


[1] C.A. Janeway Jr, P. Travers, M. Walport et al. Immunobiology: The Immune System in Health and Disease. 5th edition.New York. Garland Science, 2001.

 

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Axon ID Name Description From price
2381 WH-4-023 Orally active src-family selective lck inhibitor €90.00
1562 TWS 119 GSK-3β inhibitor €70.00
2010 TDZD 8 Selective and non-ATP-competitive inhibitor of GSK-3β €90.00
5006 Stem Cell CSD inhibitor Set Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €140.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €110.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €200.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €170.00
1635 Sotrastaurin PKC inhibitor €50.00
1923 SMI 4a ATP-competitive and selective inhibitor of Pim kinases €75.00
1633 SGI 1776 free base Pim kinase inhibitor €95.00
1303 SB 216763 GSK-3 inhibitor €85.00
1258 Necrostatin-1 RIP1 inhibitor €95.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €230.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
1401 LY 333531 mesylate PKC-β inhibitor €80.00
2362 LY 333531 hydrochloride PKC-β inhibitor €75.00
2511 IM 12 GSK-3β inhibitor attenuating neuronal differentiation of human NPCs €95.00
2311 HG-9-91-01 Potent and selective SIK inhibitor €110.00
3024 GSK'872 Potent and selective RIP3 kinase inhibitor €95.00
2466 Gö 6983 Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ €90.00
2331 FRAX 486 Bioavailable, brain penetrating inhibitor of p21-activated kinases (PAKs) €90.00
1682 Enzastaurin PKC-β inhibitor €95.00
2305 CX 6258 hydrochloride Pim kinase inhibitor €99.00
2656 CRT0066854 Selective ATP-competitive inhibitor of the atypical PKC isoenzymes €135.00
2435 CHIR99021 dihydrochloride GSK-3 inhibitor €60.00
1386 CHIR99021 GSK-3 inhibitor €60.00
1126 CHIR98014 GSK-3 inhibitor €99.00
3069 CCG-222740 Potent and selective Rho/MRTF/SRF transcriptional pathway inhibitor €145.00
2753 CCG 232601 Rho/MRTF/SRF transcriptional pathway inhibitor €160.00
1693 BIO GSK-3 inhibitor €90.00

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