Immunology
Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of bacteria and viral infections, for example. The immune system also performs surveillance of tumor cells, and immune suppression has been reported to increase the risk of certain types of cancer. Disorders of the immune system can result in a multitude of diseases. When the immune system is less active than normal, immunodeficiency occurs resulting in recurring and life-threatening infections. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms.
The immune system is composed of two major parts: the innate immune system and the adaptive immune system. The innate, or non-specific immune system comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner, and is present in all living organisms and comes into play immediately or within hours of an antigen's appearance in the body. Innate responses use phagocytic cells (neutrophils, monocytes and macrophages) and natural killer cells that use a primitive non-specific recognition system that allows them to bind, internalize and kill a variety of micro-organisms and exogenous molecules. The molecular components of innate reponse include complement, acute-phase proteins and cytokines such as interferons. The adaptive immune system however, effectuates an antigen-specific immune response and confers long-lasting or protective immunity to the host and is only found in vertebrates. This kind of immune response involves antigen-presenting cells (APCs), B and T cells. APCs are a heterogenous population of leukocytes with a immunostimulatory function[1].
[1] C.A. Janeway Jr, P. Travers, M. Walport et al. Immunobiology: The Immune System in Health and Disease. 5th edition.New York. Garland Science, 2001.
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Axon ID | Name | Description | From price | |
---|---|---|---|---|
2381 | WH-4-023 | Orally active src-family selective lck inhibitor | €90.00 | |
1562 | TWS 119 | GSK-3β inhibitor | €70.00 | |
2010 | TDZD 8 | Selective and non-ATP-competitive inhibitor of GSK-3β | €90.00 | |
5006 | Stem Cell CSD inhibitor Set | Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. | €140.00 | |
2130 | Stem Cell Alternative 2i inhibitor Set | Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €110.00 | |
5007 | Stem Cell 5i inhibitor Set | Set of five inhibitors for neural differentiation of human pluripotent stem cells. | €200.00 | |
5009 | Stem Cell 4i inhibitor Set | Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) | €170.00 | |
1635 | Sotrastaurin | PKC inhibitor | €50.00 | |
1923 | SMI 4a | ATP-competitive and selective inhibitor of Pim kinases | €75.00 | |
1633 | SGI 1776 free base | Pim kinase inhibitor | €95.00 | |
1303 | SB 216763 | GSK-3 inhibitor | €85.00 | |
1258 | Necrostatin-1 | RIP1 inhibitor | €95.00 | |
5010 | Naive Stem Cell NHSM inhibitor Set | Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs | €230.00 | |
5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
1401 | LY 333531 mesylate | PKC-β inhibitor | €80.00 | |
2362 | LY 333531 hydrochloride | PKC-β inhibitor | €80.00 | |
2511 | IM 12 | GSK-3β inhibitor attenuating neuronal differentiation of human NPCs | €95.00 | |
2311 | HG-9-91-01 | Potent and selective SIK inhibitor | €110.00 | |
3024 | GSK'872 | Potent and selective RIP3 kinase inhibitor | €95.00 | |
2466 | Gö 6983 | Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ | €90.00 | |
2331 | FRAX 486 | Bioavailable, brain penetrating inhibitor of p21-activated kinases (PAKs) | €90.00 | |
1682 | Enzastaurin | PKC-β inhibitor | €95.00 | |
2305 | CX 6258 hydrochloride | Pim kinase inhibitor | €99.00 | |
2656 | CRT0066854 | Selective ATP-competitive inhibitor of the atypical PKC isoenzymes | €135.00 | |
2435 | CHIR99021 dihydrochloride | GSK-3 inhibitor | €60.00 | |
1386 | CHIR99021 | GSK-3 inhibitor | €60.00 | |
1126 | CHIR98014 | GSK-3 inhibitor | €99.00 | |
3069 | CCG-222740 | Potent and selective Rho/MRTF/SRF transcriptional pathway inhibitor | €145.00 | |
2753 | CCG 232601 | Rho/MRTF/SRF transcriptional pathway inhibitor | €160.00 | |
1693 | BIO | GSK-3 inhibitor | €90.00 |