Immunology

Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of bacteria and viral infections, for example. The immune system also performs surveillance of tumor cells, and immune suppression has been reported to increase the risk of certain types of cancer. Disorders of the immune system can result in a multitude of diseases. When the immune system is less active than normal, immunodeficiency occurs resulting in recurring and life-threatening infections. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms.
The immune system is composed of two major parts: the innate immune system and the adaptive immune system. The innate, or non-specific immune system comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner, and is present in all living organisms and comes into play immediately or within hours of an antigen's appearance in the body. Innate responses use phagocytic cells (neutrophils, monocytes and macrophages) and natural killer cells that use a primitive non-specific recognition system that allows them to bind, internalize and kill a variety of micro-organisms and exogenous molecules. The molecular components of innate reponse include complement, acute-phase proteins and cytokines such as interferons. The adaptive immune system however, effectuates an antigen-specific immune response and confers long-lasting or protective immunity to the host and is only found in vertebrates. This kind of immune response involves antigen-presenting cells (APCs), B and T cells. APCs are a heterogenous population of leukocytes with a immunostimulatory function[1].


[1] C.A. Janeway Jr, P. Travers, M. Walport et al. Immunobiology: The Immune System in Health and Disease. 5th edition.New York. Garland Science, 2001.

 

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Axon ID Name Description From price
2434 1-Deazaadenosine Adenosine deaminase (ADA) inhibitor with cytostatic activity in vitro €140.00
2175 3PO Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. €65.00
3189 4-CPPC First potent, selective and reversible inhibitor of MIF-2 €135.00
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
3718 AB-680 ammonium salt CD73 inhibitor Inquire
3729 ABBV-CLS-484 hydrochloride Inhibitor of phosphatase PTPN1/N2 (Protein Tyrosine Phosphatase Non-Receptor Type 1 and 2), Inquire
2880 ABC294640 Selective and orally available SphK2 (or SK2) inhibitor €125.00
1291 AEG 3482 JNK inhibitor €90.00
4175 AJ2-30 First-in-class SLC15A4 inhibitor €110.00
3465 Amenamevir Potent helicase-primase inhibitor €120.00
2863 AMI-1 Inhibitor of PRMT €99.00
1369 Apilimod Cytokine inhibitor; IL-12 and IL-23 inhibitor €110.00
2500 Apilimod dimesylate Cytokine inhibitor; IL-12 and IL-23 inhibitor €110.00
1957 Apremilast PDE4 inhibitor €60.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
3433 ARB-272572 Potent, cellular active PD-L1 inhibitor €150.00
3041 ARN 3236 Potent, selective, ATP-competitive, and orally available inhibitor of SIK2 €80.00
3837 ARUK2001607 Potent, selective, and brain-penetrant PI5P4Kγ inhibitor €120.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €130.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2288 ATB 346 Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor €110.00
3299 Avibactam sodium Covalent, reversible inhibitor of β-lactamase €70.00
2226 AVL 292 Potent, selective, covalent BTK inhibitor €110.00
2692 AX-024 hydrochloride T cell receptor inhibitor €125.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
5053 Axon Ligands™ Stem cell compound library Axon Ligands™ Stem cell compound library Inquire
2669 AZ13705339 Potent and selective PAK1 inhibitor €125.00
2171 AZD1080 Selective inhibitor of GSK-3α and GSK-3β €90.00
2795 AZD1208 Pim kinase inhibitor €70.00
3771 AZD2858 Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00

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