Axon Ligands™ for Epigenetic Research

Epigenetics is typically defined as the study of heritable changes in gene expression that are not due to changes in DNA sequence. Epigenetic modifications of chromatin have been shown to play a major role in cancer onset and development. Acetylation and methylation are the most-studied chromatin marks, having fundamental functions in the epigenetic regulation of gene expression[1],[2].

Epigenetic modification of histones is a reversible process. Histone acetyltransferases (HATs) are the enzymes responsible for the introduction of acetyl groups on histones, whereas methyl groups can be introduced both on DNA and histones by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs)[3]. The removal of methyl and acetyl groups is enzymatically mediated by the action of histone demethylases (HDMs) and histone deacetylases (HDACs), respectively. In turn, epigenetic marks can be recognized by and bound to specific protein domains, such as bromodomain and malignant brain tumor (MBT). These complexes are important intermediates in the epigenetic regulation of gene expression[4].

Axon Medchem offers a wide selection of bioactive small molecules to modulate epigenetic mechanisms, serving researchers in their objective to investigate biological consequences of chromatin modifications and develop new drugs for cancer treatment.

Epigenetic products Library

For your convenience, you can order a library of all of our Epigenetics related products. Make your personal library by cherry picking products of your interest from our comprehensive list (125 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon Ligands™ - Epigenetics Library.xls                   


Modifiers of Histone

Histone Demethylase (LSD/Jumonji C)

Histone Deacetylase (HDAC)

SET domain lysine Methyltransferase (G9a/EZH2)

Histone Deacetylase (SIRT)

Arginine Methyltransferase (PRMT)

Histone Acetyltransferase (HAT)

DNA Methyltransferase (DNMT)


Recognition of modified Histone

Recognition of Acetylated Lysine (Bromodomains)                             

Recognition of Metylated Lysine (Kme/MBT)

[1] Epigenetics in Cancer. Manel Esteller.N Engl J Med 2008; 358, 1148-1159.
[2] Epigenetic protein families: a new frontier for drug discovery. CH Arrowsmith et al. Nature 2012, 11, 384-400.
[3] Histone acetyltransferases as emerging drug targets. FJ Dekker and HJ Haisma. Drug Discov. Today 2009, 14(19-20), 942-948.
[4] Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family. Filippakopoulos, P. et al. Cell 2012, 149, 214-231

Items 121 to 150 of 217 total

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Axon ID Name Description From price
3562 ML 324 Inhibitor of JMJD2 histone demethylase €90.00
2081 ML 324 dihydrochloride Inhibitor of JMJD2 histone demethylase €90.00
2733 ML329 Inhibitor of the MITF molecular pathway €110.00
2003 MLN 8237 Second generation selective Aurora A inhibitor €90.00
2505 Mocetinostat Class I selective HDAC inhibitor with broad spectrum antitumor activity €80.00
3796 MRTX1719 hydrochloride Inhibitor of the PRMT5.MTA complex Inquire
1803 MS 275 Inhibitor of HDAC (1 and 3 Selective) €60.00
3681 MS023 dihydrochloride Potent, cell-active, and Type I selective PRMT inhibitor €90.00
3469 MS1943 trifluoroacetate First-in-class EZH2 selective degrader; PROTAC €200.00
2359 Nexturastat A HDAC6 inhibitor with good selectivity over HDAC1 and HDAC8 €90.00
2928 Niraparib Potent, selective, and orally available PARP1/2 inhibitor €90.00
3409 NKL 22 HDAC inhibitor €80.00
1370 NU 1025 PARP inhibitor €80.00
2792 NVP-BSK805 Potent, selective and orally bioavailable JAK2 inhibitor €125.00
3186 NVS-BPTF-1 Potent, selective and cell active chemical probe for BPTF €180.00
2651 OAC2 Oct4 and Nanog activating compound that enhances reprogramming efficiency €60.00
3329 ODM-207 Highly potent, selective and orally active pan-BET inhibitor €140.00
2442 OF-1 Potent bromodomain inhibitor (BRPF1 and BRPF2 selective) €80.00
2077 OG-L002 hydrochloride Inhibitor of lysine specific demethylase 1 (LSD1 aka KDM1A) €125.00
3583 OICR-9429 First-in-class, potent, highly selective and cell-active antagonist of the Wdr5-MLL interaction €90.00
1464 Olaparib PARP inhibitor €50.00
2843 OSS-128167 Selective SIRT6 inhibitor €125.00
2530 OTX 015 Potent inhibitor of BRD2, BRD3, and BRD4 with clear anti-proliferative activity €110.00
3614 Parthenolide NF-κB activation inhibitor €90.00
1853 PCI 34051 HDAC8 Inhibitor €90.00
3795 PDD00017273 First-in-class, selective and cell-active PARG inhibitor  Recently added €90.00
2023 PF 03814735 ATP-competitive inhibitor of aurora kinase A and B €120.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
3695 PF-06821497 Inhibitor of Histone Lysine Methyltransferase EZH2 Inquire
3798 PF-06855800 SAM-pocket-binding (SAM competitive) PRMT5 inhibitor Inquire

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