Endocrinology

The endocrine system is a network of eight ductless glands that produce and release hormones that regulate homeostasis, metabolism, growth and development, tissue function, sexual function, reproduction, sleep and mood, among other things, into the blood. Unlike the nervous system, whose action helps the body react immediately to change, the endocrine system controls changes that happen to the body over a long period of time; from minutes, hours, to years of change. The major glands of the endocrine system are the hypothalamus, pituitary, thyroid, parathyroids, adrenals, pineal body, and the reproductive organs (ovaries and testes). The pancreas is also a part of this system; it has a role in hormone production as well as in digestion.
The hormones released by the endocrine system can be grouped into three classes based on their structure: steroids (cholesterol derivatives, secreted by the gonads, adrenal cortex, and placenta), peptides (small-chain amino acids, secreted by the pituitary, parathyroid, heart, stomach, liver, and kidneys), and amines (tyrosine derivatives, secreted from the thyroid and the adrenal medulla). These hormones affect the target cells by two different mechanisms. Nonsteroid hormones (water soluble) do not enter the cell but bind to plasma membrane receptors, and transduce their signal through second messenger systems into the target cell's interior. Steroid hormones, in contrast, pass through the plasma membrane of the target cells and act in a two step process in which they bind to nuclear membrane receptors, producing an activated hormone-receptor complex. The activated hormone-receptor complex, in turn, binds to DNA and activates specific genes, increasing the production of proteins.
The endocrine system uses cycles and negative feedback which helps to control the delicate balance of hormones in the bloodstream and regulate physiological functions. However, minor changes in the function of one or more of the glands of the endocrine system, changes in the blood's fluid and electrolyte balance, or several external factors such as stress or infection can distort the balance of hormones and lead to an endocrine disorder, or endocrine disease. Hypothyroidism, thyroid cancer, fertility issues, diabetes, and other metabolic disorders are typical examples of problems that originate from imbalances of the enodcrine system.

Items 1 to 15 of 27 total

per page
Page:
  1. 1
  2. 2
Axon ID Name Description From price
1873 Abiraterone Inhibitor of CYP17A1 €90.00
1874 Abiraterone acetate Prodrug of Abiraterone; Inhibitor of CYP17A1 €90.00
2031 AIM 100 Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) €95.00
2863 AMI-1 Inhibitor of PRMT €99.00
2819 APX-115 First-in-class pan-NADPH oxidase (Nox) inhibitor €125.00
2787 ASP 9521 Inhibitor of 17 β–hydroxysteroid dehydrogenase type 5 €75.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2210 C 7280948 Sulfone inhibitor of PRMT1 €85.00
2709 CMP5 Inhibitor of PRMT5 €95.00
2831 EPZ 015666 Potent, selective and orally available inhibitor of PRMT5 €125.00
2045 Exemestane Irreversible steroidal aromatase (CYP19A1) inhibitor €80.00
2277 FLI 06 Notch signaling inhibitor that acts early in the secretory pathway €95.00
1443 Genipin Protein cross-linker; stimulates insulin secretion €55.00
2267 GSK 1838705A Potent IGF-IR and insulin receptor (IR) kinase inhibitor with additional affinity for ALK €110.00

Items 1 to 15 of 27 total

per page
Page:
  1. 1
  2. 2
Please wait...