Diabetes & Metabolism

Diabetes mellitus and hypertension are two of the most common diseases in Westernized, industrialized civilizations, and the frequency of both diseases increases with increasing age. Diabetes mellitus is characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action or both, and associated with a considerably increased cardiovascular risk, peripheral vascular diseases, stroke, retinopathy, and nephropathy. Two types of diabetes mellitus are recognized based on the presumed etiology. In type 1 diabetes, the body fails to produce insulin as a result of an auto-immune reaction that destroys the islet cells in the pancreas that produce insulin, and daily insulin injections are required. Type 1 diabetes is usually diagnosed during childhood or early adolescence and it affects about 1 in every 600 children. Type 2 diabetes is the result of failure to produce sufficient insulin and insulin resistance. Elevated blood glucose levels are managed with reduced food intake, increased physical activity, and eventually oral medications or insulin. Type 2 diabetes is typically diagnosed during adulthood. However with the increasing incidence of childhood obesity and concurrent insulin resistance, the number of children diagnosed with type 2 diabetes has also increased worldwide.
The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. Evidence is accumulating that insulin resistance, or hyperinsulinemia, may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors.

Items 46 to 60 of 234 total

per page
Page:
  1. 2
  2. 3
  3. 4
  4. 5
  5. 6
Axon ID Name Description From price
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2976 BI 01383298 Potent and selective Na+/citrate cotransporter inhibitor €95.00
2867 Biliatresone Reactive natural toxin Inquire
1693 BIO GSK-3 inhibitor €95.00
2506 BMS 303141 Cell-permeable ATP-citrate lyase (ACL) inhibitor €90.00
2749 BT-11 First-in-class, orally active LANCL2 binding compound €105.00
2334 BT2 Allosteric inhibitor of BCKDC kinase (BDK) and Mcl-1 inhibitor €95.00
1257 BTS 54-505 5-HT uptake inhibitor €85.00
1756 BVT 2733 hydrochloride Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 €115.00
2662 CAIX Inhibitor S4 Carbonic anhydrase (CA) IX/XII inhibitor €90.00
2803 Cambinol Inhibitor of SIRT1 and SIRT2 €95.00
2585 CBR 5884 Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) €90.00
2699 CCT251236 HSF1 stress pathway inhibitor €145.00
1609 CDIBA cPLA2 inhibitor €125.00
2684 CDN1163 Allosteric Activator of SERCA2b €90.00

Items 46 to 60 of 234 total

per page
Page:
  1. 2
  2. 3
  3. 4
  4. 5
  5. 6
Please wait...