Diabetes & Metabolism

Diabetes mellitus and hypertension are two of the most common diseases in Westernized, industrialized civilizations, and the frequency of both diseases increases with increasing age. Diabetes mellitus is characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action or both, and associated with a considerably increased cardiovascular risk, peripheral vascular diseases, stroke, retinopathy, and nephropathy. Two types of diabetes mellitus are recognized based on the presumed etiology. In type 1 diabetes, the body fails to produce insulin as a result of an auto-immune reaction that destroys the islet cells in the pancreas that produce insulin, and daily insulin injections are required. Type 1 diabetes is usually diagnosed during childhood or early adolescence and it affects about 1 in every 600 children. Type 2 diabetes is the result of failure to produce sufficient insulin and insulin resistance. Elevated blood glucose levels are managed with reduced food intake, increased physical activity, and eventually oral medications or insulin. Type 2 diabetes is typically diagnosed during adulthood. However with the increasing incidence of childhood obesity and concurrent insulin resistance, the number of children diagnosed with type 2 diabetes has also increased worldwide.
The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. Evidence is accumulating that insulin resistance, or hyperinsulinemia, may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors.

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Axon ID Name Description From price
2692 AX-024 hydrochloride T cell receptor inhibitor €125.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
5053 Axon Ligands™ Stem cell compound library Axon Ligands™ Stem cell compound library Inquire
2340 AZ-GHS-22 Orally available Ghrelin receptor (GHS-R1a) inverse agonist €160.00
2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β €110.00
2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
3062 AZD1656 Glucokinase (GK) activator €165.00
2567 Azoramide Modulator of the unfolded protein response (UPR) with antidiabetic activity €65.00
2957 BACE-2 Inhibitor Potent and highly selective BACE 2 inhibitor €135.00
2660 BAY-876 Inhibitor of glucose transporter 1 (GLUT1) €105.00
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2976 BI 01383298 Potent and selective Na+/citrate cotransporter inhibitor €95.00
3181 BI 99179 Potent, selective and orally active inhibitor of type I fatty acid synthase (FAS) €150.00
3182 BI 99990 Negative control of BI 99179 as a selective inhibitor of type I fatty acid synthase €130.00
2867 Biliatresone Reactive natural toxin Inquire

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