Diabetes & Metabolism

Diabetes mellitus and hypertension are two of the most common diseases in Westernized, industrialized civilizations, and the frequency of both diseases increases with increasing age. Diabetes mellitus is characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action or both, and associated with a considerably increased cardiovascular risk, peripheral vascular diseases, stroke, retinopathy, and nephropathy. Two types of diabetes mellitus are recognized based on the presumed etiology. In type 1 diabetes, the body fails to produce insulin as a result of an auto-immune reaction that destroys the islet cells in the pancreas that produce insulin, and daily insulin injections are required. Type 1 diabetes is usually diagnosed during childhood or early adolescence and it affects about 1 in every 600 children. Type 2 diabetes is the result of failure to produce sufficient insulin and insulin resistance. Elevated blood glucose levels are managed with reduced food intake, increased physical activity, and eventually oral medications or insulin. Type 2 diabetes is typically diagnosed during adulthood. However with the increasing incidence of childhood obesity and concurrent insulin resistance, the number of children diagnosed with type 2 diabetes has also increased worldwide.
The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. Evidence is accumulating that insulin resistance, or hyperinsulinemia, may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors.

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Axon ID Name Description From price
1873 Abiraterone Inhibitor of CYP17A1 €90.00
1874 Abiraterone acetate Prodrug of Abiraterone; Inhibitor of CYP17A1 €90.00
2915 CID 1375606 Selective surrogate agonist for GPR27 €95.00
2569 JNJ 63533054 Potent, brain-penetrant, selective agonist of GPR139 €90.00
2609 NCRW0005-F05 GPR139 antagonist; useful tool to study GPR139 pharmacology €125.00
2026 PF 04981517 Inhibitor of Cytochrome P450 3A4 (CYP3A4) €110.00
1595 PPP hydrochloride CYP2B6 inhibitor €95.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00
2922 Sulfaphenazole CYP2C9 inhibitor; Antibiotic €60.00
2124 TAK 700 Potent and highly selective inhibitor of 17,20-lyase (CYP17A1) €105.00
1564 Tienilic Acid CYP2C10 Inhibitor €75.00
2628 TMS CYP1B1 inhibitor that induces apoptosis in human cancer cells €75.00

12 Item(s)

per page
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