Diabetes & Metabolism

Diabetes mellitus and hypertension are two of the most common diseases in Westernized, industrialized civilizations, and the frequency of both diseases increases with increasing age. Diabetes mellitus is characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action or both, and associated with a considerably increased cardiovascular risk, peripheral vascular diseases, stroke, retinopathy, and nephropathy. Two types of diabetes mellitus are recognized based on the presumed etiology. In type 1 diabetes, the body fails to produce insulin as a result of an auto-immune reaction that destroys the islet cells in the pancreas that produce insulin, and daily insulin injections are required. Type 1 diabetes is usually diagnosed during childhood or early adolescence and it affects about 1 in every 600 children. Type 2 diabetes is the result of failure to produce sufficient insulin and insulin resistance. Elevated blood glucose levels are managed with reduced food intake, increased physical activity, and eventually oral medications or insulin. Type 2 diabetes is typically diagnosed during adulthood. However with the increasing incidence of childhood obesity and concurrent insulin resistance, the number of children diagnosed with type 2 diabetes has also increased worldwide.
The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. Evidence is accumulating that insulin resistance, or hyperinsulinemia, may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors.

Items 1 to 15 of 258 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Axon ID Name Description From price
2445 ZLN 024 Allosteric activator of AMP-activated protein kinase (AMPK) €90.00
2379 ZLN 005 Selective transcriptional regulator of peroxisome PPAR-γ coactivator-1α (PGC-1α). €45.00
2543 ZCZ 011 Brain penetrant CB1 positive allosteric modulator (PAM) €125.00
1273 Zamifenacin fumarate Muscarinic M3 antagonist €115.00
2337 XCT 790 ERRα inverse agonist and potent mitochondrial uncoupler €120.00
1991 WYE 672 Liver X receptor (LXR) agonist €125.00
2044 Voriconazole Orally bioavailable CYP51 inhibitor; Antifungal agent €85.00
1631 Vildagliptin DPP4 inhibitor €95.00
2938 Verinurad Highly potent and selective inhibitor of the renal urate transporter URAT1 €95.00
3106 Valsartan Potent, highly selective, and orally active AT1 antagonist €76.00
2696 URB602 Non-competitive inhibitor of MAGL €60.00
2581 UR 1102 Selective inhibitor of the renal urate transporter URAT1 €105.00
1562 TWS 119 GSK-3β inhibitor €70.00
3022 TUPS Soluble epoxide hydrolase inhibitor €135.00
3078 TUG-1375 Potent GPR43 receptor agonist (FFA2) €180.00

Items 1 to 15 of 258 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Please wait...