Diabetes & Metabolism

Diabetes mellitus and hypertension are two of the most common diseases in Westernized, industrialized civilizations, and the frequency of both diseases increases with increasing age. Diabetes mellitus is characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action or both, and associated with a considerably increased cardiovascular risk, peripheral vascular diseases, stroke, retinopathy, and nephropathy. Two types of diabetes mellitus are recognized based on the presumed etiology. In type 1 diabetes, the body fails to produce insulin as a result of an auto-immune reaction that destroys the islet cells in the pancreas that produce insulin, and daily insulin injections are required. Type 1 diabetes is usually diagnosed during childhood or early adolescence and it affects about 1 in every 600 children. Type 2 diabetes is the result of failure to produce sufficient insulin and insulin resistance. Elevated blood glucose levels are managed with reduced food intake, increased physical activity, and eventually oral medications or insulin. Type 2 diabetes is typically diagnosed during adulthood. However with the increasing incidence of childhood obesity and concurrent insulin resistance, the number of children diagnosed with type 2 diabetes has also increased worldwide.
The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. Evidence is accumulating that insulin resistance, or hyperinsulinemia, may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors.

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Axon ID Name Description From price
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00
2803 Cambinol Inhibitor of SIRT1 and SIRT2 €95.00
3769 FHD-286 Selective inhibitor of the BAF chromatin remodeling complex ATPases (BRG1/BRM) Inquire
2843 OSS-128167 Selective SIRT6 inhibitor €125.00
2704 Salermide Potent inhibitor of SIRT1 and SIRT2 €95.00
1956 Selisistat Potent and selective SIRT1 inhibitor €90.00
3623 SGC-SMARCA-BRDVIII Potent, highly selective and cell-active SMARCA2/4 and PB1(5) bromodomain inhibitor €90.00
2453 SirReal 2 SIRT2 inhibitor with >1000 fold selectivity over SIRT1 and SIRT3 €95.00
2968 SIRT7 inhibitor 97491 Inhibitor of SIRT7 €135.00
2008 Tenovin 1 Activates p53 through inhibition of SIRT 1 and 2 €70.00
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00

12 Item(s)

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