Diabetes & Metabolism

Diabetes mellitus and hypertension are two of the most common diseases in Westernized, industrialized civilizations, and the frequency of both diseases increases with increasing age. Diabetes mellitus is characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action or both, and associated with a considerably increased cardiovascular risk, peripheral vascular diseases, stroke, retinopathy, and nephropathy. Two types of diabetes mellitus are recognized based on the presumed etiology. In type 1 diabetes, the body fails to produce insulin as a result of an auto-immune reaction that destroys the islet cells in the pancreas that produce insulin, and daily insulin injections are required. Type 1 diabetes is usually diagnosed during childhood or early adolescence and it affects about 1 in every 600 children. Type 2 diabetes is the result of failure to produce sufficient insulin and insulin resistance. Elevated blood glucose levels are managed with reduced food intake, increased physical activity, and eventually oral medications or insulin. Type 2 diabetes is typically diagnosed during adulthood. However with the increasing incidence of childhood obesity and concurrent insulin resistance, the number of children diagnosed with type 2 diabetes has also increased worldwide.
The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. Evidence is accumulating that insulin resistance, or hyperinsulinemia, may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors.

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Axon ID Name Description From price
2898 AC 264613 Potent, selective, and metabolically stable PAR2 agonist €95.00
2275 AdipoRon Orally active small-molecule AdipoR agonist €80.00
2405 AMG 837 calcium salt Orally bioavailable partial agonist of GPR40 (FFA1) €110.00
2541 APD 597 Orally bioavailable selective GPR119 agonist €125.00
2380 APD 668 Potent and selective, orally active GPR119 agonist €125.00
2794 AR 420626 GPR41 receptor agonist (FFA3) €95.00
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2915 CID 1375606 Selective surrogate agonist for GPR27 €95.00
2015 CP 945598 CB1 antagonist €135.00
2119 CP 945598 hydrochloride CB1 antagonist €135.00
2942 DJ-V-159 Selective GPRC6A agonist €95.00
2727 Elafibranor Dual PPARα/δ agonist €90.00
1404 Fluticasone propionate Glucocorticoid agonist €75.00
1907 GLP-1R agonist DMB GLP-1 Receptor (GLP1R) Agonist €99.00
2582 GSK 137647A Potent and selective FFA4/GPR120 agonist €70.00

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