CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2261 ZD 9379 Antagonist of the glycine site on the NMDA receptor complex €95.00
1312 YM 90K hydrochloride AMPA antagonist €85.00
1259 YM 298198 hydrochloride, desmethyl mGluR1 antagonist €105.00
1260 YM 298198 hydrochloride mGluR1 antagonist €95.00
1425 VU 29 Positive allosteric modulator (PAM) of mGluR5 €125.00
1845 VU 0364770 Positive allosteric modulator (PAM) of mGluR4 €80.00
1830 VU 0364439 Positive allosteric modulator (PAM) of mGluR4 €115.00
1842 VU 0361737 Positive allosteric modulator (PAM) of mGluR4 €85.00
1795 VU 0360223 mGluR5 antagonist €115.00
1894 VU 0357121 Positive allosteric modulator (PAM) of mGluR5 €85.00
2640 TFB-TBOA Very potent blocker of human excitatory amino acid transporters (EAAT1-2) €145.00
2708 TCN-201 NMDA NR2A antagonist €105.00
2427 TBOA ammonia salt, L- Very potent blocker of EAAT1–3 €135.00
1788 S 18986 Positive allosteric modulator of AMPA receptor €105.00
2601 RO 25-6981 maleate NMDA NR2B antagonist €110.00

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