CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1197 Zopiclone Benzodiazepine agonist €75.00
1646 Zaleplon GABAA-α1 agonist €65.00
1422 TP 003 GABAA-α3 agonist €80.00
3119 Stiripentol PAM of GABAA  Recently added €70.00
1195 SL 651498 GABAA-α2 agonist €95.00
2833 PK 11195, N-Desmethyl- Radioligand precursor of the benzodiazepine antagonist PK 11195 €105.00
2784 PK 11195, (R)-(-)-N-Desmethyl- Radioligand precursor of the benzodiazepine antagonist (R)-(-)-PK 11195 €145.00
2785 PK 11195, (R)-(-)- Benzodiazepine antagonist. €125.00
1208 PK 11195 Benzodiazepine antagonist €65.00
1594 Pagoclone, (+)- GABAA-α2 and GABAA-α3 agonist €135.00
1457 NS 11394 PAM of GABAA €115.00
1121 NBI 34060 PAM of GABAA-α1 €95.00
1196 L 838417 GABAA-α1 antagonist €95.00
1820 GS 39783 PAM of GABA-B Receptor €99.00
1301 Gabapentin GABA modulator; Anti-convulsant €65.00

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