CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2543 ZCZ 011 Brain penetrant CB1 positive allosteric modulator (PAM) €125.00
1924 SR 144528 CB2 receptor antagonist and/or an inverse agonist €120.00
1220 SR 141716 hydrochloride CB1 antagonist €70.00
1712 SLV 319, rac-(±)- Racemate of CB1 antagonist Ibipinabant (Axon 1713) €110.00
1714 SLV 319, (R)-(+)- Inactive enantiomer of SLV 319 €95.00
1713 SLV 319 CB1 antagonist €105.00
1211 Palmitoylethanolamide Endocannabinoid; GPR55 agonist €75.00
1550 MK 0364 CB1 antagonist/inverse agonist €95.00
2092 MBX 2982 Potent and selective GPR119 agonist €125.00
1418 JWH 133 CB2 agonist €95.00
1574 Iodopravadoline CB2 antagonist €75.00
1440 HU 308 CB2 agonist €135.00
1925 GW 842166X Cannabinoid CB2 receptor agonist €110.00
2119 CP 945598 hydrochloride CB1 antagonist €135.00
2015 CP 945598 CB1 antagonist €135.00

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