CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1273 Zamifenacin fumarate Muscarinic M3 antagonist €115.00
2739 VU 6008667 Selective NAM of M5 mAChR (CHRM5) €105.00
1943 VU 0365114 Selective PAM of M5 mAChR (CHRM5) €115.00
1703 VU 0357017 hydrochloride PAM of M1 mAChR €115.00
1787 VU 0255035 Selective M1 mAChR Antagonist €120.00
1786 VU 0238429 Selective PAM of M5 mAChR (CHRM5) €105.00
1483 VU 0152100 PAM of M4 mAChR €85.00
1988 VU 0029767 PAM of mAChR M1 that potentiates the agonistic effect of Ach €120.00
2074 Varenicline tartrate Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist €90.00
1384 Varenicline dihydrochloride Nicotinic acetylcholine receptor agonist €85.00
2049 Tolterodine L-tartrate Muscarinic receptor (mAChR) antagonist €85.00
2463 TBPB Allosteric activator of the M1 acetylcholine receptor devoid of M2-M5 activity. €105.00
2908 PNU 282987 hydrochloride nAChR agonist (α7 sub-unit selective) €90.00
2109 PHA 543613 dihydrochloride nAChR agonist (α7 sub-unit selective) €115.00
1679 MDL 201012 Muscarinic M3 antagonist €110.00

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