CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1562 TWS 119 GSK-3β inhibitor €70.00
2010 TDZD 8 Selective and non-ATP-competitive inhibitor of GSK-3β €90.00
5006 Stem Cell CSD inhibitor Set Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €155.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €110.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €220.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD 0325901, and CHIR 99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €190.00
1303 SB 216763 GSK-3 inhibitor €85.00
2546 PF 06447475 Potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor €85.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €260.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €220.00
2493 LRRK2-IN-1 Potent, ATP-competitive and selective inhibitor of LRRK2 €85.00
2511 IM 12 GSK-3β inhibitor attenuating neuronal differentiation of human NPCs €95.00
2181 GSK 2578215A Potent and highly selective LRRK2 inhibitor €125.00
2348 GNE 7915 Potent, selective, metabolically stable, and brain-penetrable LRRK2 inhibitor €110.00
2331 FRAX 486 Bioavailable, brain penetrating inhibitor of p21-activated kinases (PAKs) €90.00

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