CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1305 XE 991 dihydrochloride KCNQ channel and M-current blocker €90.00
1987 XE 991 KCNQ channel and M-current blocker €90.00
1657 S 9947 Ikur/Kv1.5 channel Inhibitor €125.00
2252 Retigabine dihydrochloride KCNQ channel opener; Anti-convulsant €90.00
1525 Retigabine KCNQ channel opener; Anti-convulsant €90.00
2403 PK-THPP Potent TASK-3 antagonist with selectivity over a wide range of potassium channels €145.00
2094 NS 6180 KCa3.1 channel blocker €90.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
2854 NS 1619 Selective activator of large-conductance Ca2+-activated potassium (BK) channels €95.00
1647 NN 414 K+ channel opener (SUR1/Kir6.2 selective) €90.00
2840 ML 365 Potent and selective inhibitor of the TASK-1 potassium channel €135.00
2872 ML 335 Selective activator of the TREK-1 and TREK-2 potassium channel €115.00
2436 ML 297 First potent and selective activator of the GIRK potassium channel €95.00
2615 ML 252 Selective and brain penetrant KCNQ2 inhibitor €95.00
2747 ML 213 KCNQ2/KCNQ4 channel opener €75.00

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