CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2878 ZL006 Selective inhibitor of the nNOS-PSD-95 interaction €105.00
1216 Zardaverine PDE3 and PDE4 inhibitor €75.00
2159 Z-VAD-FMK Pan-caspase inhibitor with in vivo activity Inquire
2911 Y 29794 tosylate Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor €125.00
1725 WY 46689 Metabolite of Venlafaxine; SNRI €75.00
1723 WY 45960 hydrochloride Metabolite of Venlafaxine; SNRI €95.00
1724 WY 45494 hydrochloride Metabolite of Venlafaxine; SNRI €75.00
2325 WAY 316606 hydrochloride Potent inhibitor of sFRP-1 that stimulates Wnt signaling €85.00
2670 VU6001221 Choline transporter inhibitor €125.00
1727 Venlafaxine hydrochloride SNRI €65.00
2106 Valdecoxib Selecive COX-2 inhibitor €80.00
2696 URB602 Non-competitive inhibitor of MAGL €60.00
2118 UPF 648 Potent inhibitor of kynurenine-3-monooxygenase (KMO) €105.00
2369 UPF 1069 PARP-2 inhibitor with >26 fold selectivity over PARP1 €75.00
1225 U 73122 PLC inhibitor €95.00

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