Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2551 Alda 1 Small molecule activator of ALDH2 €65.00
1884 Alectinib Orally available and selective ALK inhibitor €70.00
2930 Alofanib Allosteric inhibitor of FGFR2 €90.00
3549 Aloperine Potent multifunctional anti-tumor agent €50.00
2925 Alpelisib PI3K inhibitor (p110-α specific) €90.00
2062 Alprostadil Prostaglandin EP (1-4) receptor antagonist €125.00
N0001 Altemicidin Small bioactive molecule with acaricidal and antitumor activity Inquire
3946 Altiratinib Balanced inhibitor for MET, TIE2 (TEK), and VEGFR2 (KDR) kinases Inquire
2948 AM 580 RAR-α agonist €95.00
2971 Amcasertib First-in-class stemness kinase inhibitor €145.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
1916 AMG 208 Inhibitor of c-MET receptor tyrosine kinase (RTK) €95.00
2639 AMG 232 Potent, selective, and orally bioavailable MDM2-p53 inhibitor €120.00
1768 AMG 706 Multiple receptor tyrosine kinase inhibitor €105.00
2405 AMG 837 calcium Orally bioavailable partial agonist of GPR40 (FFA1) €90.00
1783 AMG 900 Aurora inhibitor (non-specific) €110.00
3686 AMG-176 Potent and selective Mcl-1 inhibitor €490.00
3945 AMG-337 Potent and exquisitely selective inhibitor of wild-type and some mutant forms of c-Met Inquire
3827 AMG-511 Orally bioavailable, highly potent and selective pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor Inquire
4071 AMG-925 Potent, selective, and orally available FLT3/CDK4 dual inhibitor Inquire
3575 AMG510 Highly potent, selective, and orally bioavailable KRAS-G12C inhibitor €90.00
2863 AMI-1 Inhibitor of PRMT €99.00
2368 Amuvatinib RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met €105.00
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00
1490 Anacardic acid A HAT inhibitor €60.00
3316 Anastrozole Potent, highly selective, and orally active aromatase inhibitor €50.00
3008 AOH1160 First-in-class, potent and orally available PCNA inhibitor €120.00
4030 AOH1996 Orally available PCNA inhibitor €140.00
1857 AP 24534 BCR-ABL kinase inhibitor (including T315I mutation) €70.00

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