Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2517 Napabucasin Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 €105.00
2928 Niraparib Potent, selective, and orally available PARP1/2 inhibitor  Recently added Inquire
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00
1402 NSC 348884 NPM inhibitor €120.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
1370 NU 1025 PARP inhibitor €80.00
1463 NU 7441 DNA-PK inhibitor €55.00
2599 NVP-TNKS656 Selective and orally active TNKS inhibitor and antagonist of Wnt pathway activity €95.00
1379 PF 477736 CHK1 inhibitor €70.00
2690 PHA-767491 Dual CDC7/CDK9 kinase inhibitor €95.00
2420 PTC 209 Inhibitor of the canonical self-renewal regulator BMI-1 €125.00
1911 RAD51 inhibitor B02 Inhibitor of RAD51 €95.00
1705 REP 3123 dihydrochloride MetRS inhibitor €125.00
1704 REP 8839 MetRS inhibitor €125.00
1691 RG 108 DNA methyltransferase inhibitor €80.00

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