Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
3412 DTHIB Direct and selective HSF1 inhibitor  Recently added €90.00
2701 EED226 Potent, selective and orally bioavailable PRC2 inhibitor €105.00
3340 ETC-206 Potent, selective and orally available MNK1/2 inhibitor €130.00
2975 Fatostatin hydrobromide Specific inhibitor of SREBP cleavage-activating protein (SCAP) €90.00
2318 FC 99 hydrochloride Inhibitor of TLR3 expression and inflammatory responses. €95.00
2384 FDI 6 Inhibitor of the Forkhead box protein M1 (FOXM1) €99.00
3027 FEN1 inhibitor 1 Potent flap endonuclease-1 (FEN1) inhibitor €135.00
2959 FM19G11 Potent HIFα inhibitor €95.00
2157 FQI 1 Inhibitor of α-globin transcription factor CP2 (LSF) €95.00
2885 GeA-69 Selective allosteric and cell-active PARP14 MD2 inhibitor €95.00
3233 Gemcitabine hydrochloride Specific inhibitor of DNA synthesis; Antimetabolite €50.00
2198 Genz 644282 Topo I inhibitor lacking MDR1 and BCRP affinity €95.00
2390 HAMNO Novel protein interaction inhibitor of replication protein A (RPA) €85.00
2034 HIF-2 inhibitor 2 Allosteric inhibitor of HIF-2 €95.00
2614 HIF-2a Translation Inhibitor 76 HIF-2a translation inhibitor that works independent of mTOR €70.00

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