Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1687 (±)-E-Homocamptothecin Potent topoisomerase I (Topo 1) inhibitor €120.00
2537 1,5-Isoquinolinediol PARP1 inhibitor and neuroprotective agent €50.00
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
1496 3-Aminobenzamide Competitive small molecule inhibitor of PARP €40.00
1902 4μ8C IRE1α inhibitor €105.00
3419 5-Bromo-2’-deoxyuridine Thymidine analog; Labeling agent of cell proliferation €50.00
1529 AG 014699 PARP1 inhibitor €60.00
3834 Alantolactone STAT3 inhibitor; NLRP3 inhibitor €90.00
3008 AOH1160 First-in-class, potent and orally available PCNA inhibitor €120.00
4030 AOH1996 Orally available PCNA inhibitor €140.00
2137 APE1 Inhibitor III Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €110.00
2136 AR03 Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €105.00
3220 ARN24139 Orally active topoisomerase II poison €130.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €130.00
2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) €95.00
4140 AZD0156 Selective and orally active ATM inhibitor Inquire
2241 AZD2461 PARP inhibitor with poor P-glycoprotein substrate qualities €95.00
3800 AZD4573 Inhibitor of CDK9 Inquire
4068 AZD7648 DNA-PK inhibitor Inquire
1399 AZD7762 hydrochloride CHK inhibitor €60.00
3935 BAY-1251152 Potent and highly selective CDK9/P-TEFb inhibitor Inquire
3760 Belzutifan Second-generation potent, selective and orally active HIF-2α inhibitor €280.00
2301 BIBR 1532 Potent and selective telomerase inhibitor inducing senescence in human cancer cells. €70.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
3786 BP-1-102 Orally bioavailable STAT3 inhibitor €90.00
3394 CADD522 Potent inhibitor of RUNX2-DNA binding €90.00
3932 CCT-245737 Orally active, potent and selective CHK1 inhibitor Inquire
2699 CCT251236 HSF1 stress pathway inhibitor €130.00
1611 CGP 57380 Mnk1 inhibitor €95.00
1636 CHIR124 CHK1 inhibitor €60.00

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