Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   


[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

Items 1 to 30 of 71 total

per page
  1. 1
  2. 2
  3. 3
Axon ID Name Description From price
1892 1-NM-PP1 Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) €95.00
2496 2,5-Dimethylcelecoxib Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
3957 A-1155463 dihydrochloride BH3 mimetic Ligand of BCL protein BCL-XL Inquire
4008 A-1210477 Potent and selective inhibitor of MCL-1 Inquire
3972 A-1331852 BH3 mimetic Ligand of BCL protein BCL-XL €120.00
1873 Abiraterone Inhibitor of CYP17A1 €90.00
1874 Abiraterone acetate Prodrug of Abiraterone; Inhibitor of CYP17A1 €90.00
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €70.00
3821 ABT-263 Potent, selective and orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins Inquire
1884 Alectinib Orally available and selective ALK inhibitor €70.00
3686 AMG-176 Potent and selective Mcl-1 inhibitor €490.00
1456 AZD0530 difumarate Inhibitor of SRC and ABL tyrosine kinases €70.00
2153 AZD3463 Potent inhibitor of ALK and IGF1R €105.00
3814 AZD4320 BH3-mimetic inhibitor of BCL-2 protein Inquire
3731 AZD5991 BH3-Groove binding Mcl-1 inhibitor Inquire
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
3714 BCL-201 dihydrochloride BH3-mimetic inhibitor of BCL-2 protein Inquire
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
3047 BI-6C9 Inhibitor of BID protein €145.00
3295 BIA TMBIM6 antagonist €120.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor €80.00
3431 BTSA1 Potent activator of proapoptotic BAX €110.00
3481 BTYNB isomer Ring-closed isomer of BTYNB €110.00
3931 CEP-28122 Highly potent, selective and orally active ALK inhibitor Inquire
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
1654 CP 100356 hydrochloride P-gp inhibitor €90.00
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €100.00
3200 DCLK1-IN-1 Potent, selective and orally bioavailable DCLK1/2 inhibitor €140.00
3518 DCZ0805 NF-κB activation inhibitor €130.00
3766 DT-2216 Selective B-cell lymphoma-extra large (Bcl-XL) targeted protein degrader Inquire

Items 1 to 30 of 71 total

per page
  1. 1
  2. 2
  3. 3
Please wait...