Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1873 Abiraterone Inhibitor of CYP17A1 €90.00
1874 Abiraterone acetate Prodrug of Abiraterone; Inhibitor of CYP17A1 €90.00
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €120.00
1456 AZD 0530 difumarate Inhibitor of SRC and ABL tyrosine kinases €105.00
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €105.00
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor  Recently added €80.00
1884 CH 5424802 Orally available and selective ALK inhibitor €95.00
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
1654 CP 100356 hydrochloride P-gp inhibitor €125.00
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €95.00
2496 Dimethylcelecoxib, 2,5- Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
1896 Elacridar hydrochloride P-gp inhibitor (3rd generation ABCB1 modulator) €80.00
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00

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