Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1126 CHIR 98014 GSK-3 inhibitor €105.00
1386 CHIR 99021 GSK-3 inhibitor €65.00
2435 CHIR 99021 dihydrochloride GSK-3 inhibitor €70.00
1976 CID 2011756 ATP-competitive and cell-permeable PKD inhibitor €125.00
1627 CID 755673 PKD inhibitor €125.00
2202 CK2 inhibitor 10 Potent and ATP-competitive inhibitor of CK2 €105.00
1537 CP 724714 ErbB-2/HER2 kinase inhibitor €80.00
2656 CRT0066854 Selective ATP-competitive inhibitor of the atypical PKC isoenzymes €135.00
2992 CTx-0294885 Broad-spectrum kinase inhibitor  Recently added €90.00
1965 CX 4945 hydrochloride Inhibitor of Casein kinase 2 (CK2) €105.00
2305 CX 6258 hydrochloride Pim kinase inhibitor €99.00
1392 Dasatinib Bcr-Abl and Src tyrosine kinase inhibitor €90.00
2123 DCC 2036 An orally active Bcr-ABL inhibitor €125.00
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €95.00
1682 Enzastaurin PKC-β inhibitor €95.00

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