Cell Signaling & Oncology
The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].
Cell Signaling and Oncology products Library
For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
 Axon 5051 - Cell signaling and Oncology Library.xls |
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[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2467 | (+)-ITD-1 | Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis | €165.00 | |
| 1744 | A 77-01 | TGF-βR 1 inhibitor; ALK 5 inhibitor | €80.00 | |
| 1421 | A 83-01 | TGF-βR 1 inhibitor; ALK 5 inhibitor | €70.00 | |
| 4168 | BMS-986260 | Potent, selective and orally bioavailable TGF-βR 1 inhibitor | €120.00 | |
| 3914 | CDD-1653 | First-in-class, highly potent, and selective BMPR2 kinase inhibitor | €110.00 | |
| 1832 | GW 788388 | TGF-βR 1 inhibitor | €50.00 | |
| 2236 | IN 1130 | TGF-βR 1 inhibitor | €95.00 | |
| 2323 | ITD 1 | Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis | €105.00 | |
| 1509 | LDN 193189 hydrochloride | Highly potent small molecule inhibitor of BMP type I receptors ALK2, ALK3, and ALK6 | €65.00 | |
| 3552 | LDN 212854 | Potent ALK2-biased BMP type I receptor kinase inhibitor | €110.00 | |
| 2201 | LDN 212854 trihydrochloride | Potent ALK2-biased BMP type I receptor kinase inhibitor | €110.00 | |
| 1491 | LY 2157299 | TGF-βR2 inhibitor | €60.00 | |
| 3892 | LY-3200882 | TGF-βR 1 inhibitor | Inquire | |
| 3404 | LY-364947 | Potent, selective and ATP-competitive TGF-βR 1 inhibitor | €90.00 | |
| 1661 | SB 431542 | TGF-βR1 inhibitor; ALK inhibitor | €70.00 | |
| 2197 | SB 505124 | Selective inhibitor of TGF-β type I receptors ALK4 and ALK5 | €95.00 | |
| 2285 | SB 525334 | Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor | €105.00 | |
| 1387 | SD 208 | TGF-βR 1 inhibitor | €50.00 | |
| 5004 | Stem Cell LSB inhibitor Set | Set of BMP inhibitor LDN 193189 (Axon 1509) and TGF-β inhibitor SB 431542 (Axon 1661) | €90.00 | |
| 5005 | Stem Cell LSC inhibitor Set | Set of LDN 193189 HCl, SB 431542 and CHIR99021, inhibitors of BMP, TGF-β, and GSK-3 resp. | €130.00 | |
| 3076 | TJ191 | Potent and selective anti-cancer agent targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells | €120.00 | |