Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2008 Tenovin 1 Activates p53 through inhibition of SIRT 1 and 2 €70.00
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00
2339 TH 1834 Tip60 histone acetyltransferase inhibitor €135.00
2180 TMP 195 HDAC inhibitor (class IIA selective) €110.00
2004 Tubastatin A hydrochloride Potent and selective HDAC6 inhibitor €95.00
2893 Tucidinostat Orally bioavailable HDAC inhibitor (1, 2, 3, 10 Selective) €95.00
2518 UF 010 Class I selective HDAC inhibitor that inhibits cancer cell proliferation €60.00
1789 UNC 0224 Inhibitor of G9a HMTase €85.00
2418 UNC 0379 Substrate competitive inhibitor of the H4K20 HMTase SETD8 €125.00
1841 UNC 0631 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
1889 UNC 0638 Inhibitor of G9a (EHMT2)/GLP (EHMT1) €85.00
1840 UNC 0646 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
2411 WDR5-0103 Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL €90.00
2674 YUKA1 Selective inhibitor of KDM5A demethylase €125.00

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